Evaluation of n-hexane extract of Viola betonicifolia for its neuropharmacological properties.

Journal of Natural Medicines
Naveed MuhammadIkramul Haq

Abstract

Viola betonicifolia (whole plant) has been used as a sedative and in various nervous disorders in Pakistani traditional medicines. The n-hexane extract of the whole plant of V. betonicifolia (HEVB) was investigated for neuropharmacological properties such as anxiolytic, muscle relaxant, sleep induction, antidepressant and sedative to ascertain its folk use. Anxiolytic activity was tested using the staircase test, while the muscle relaxing property of the extract was tested in various muscle relaxant paradigms, i.e. chimney test, traction test, rota rod and inclined plane. In anxiolytic and muscle relaxant tests, HEVB (0.3, 0.4 and 0.5 g/kg, i.p.), diazepam (1 mg/kg, i.p.) or distilled water (10 ml/kg i.p.) were administered 30, 60 and 90 min before performing the tests in mice. HEVB was also screened for a sleep-inducing effect. The antidepressant activity was determined by using the forced swimming test (FST), while line crossing in a special box was used for locomotor activity. HEVB showed a significant (P < 0.05) dose-dependent anxiolytic action in the staircase test. In muscle relaxant paradigms, a dose-dependent muscle relaxation was observed. For the phenobarbitone sleep induction test, HEVB notably (P < 0.05) reduced the...Continue Reading

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Citations

Apr 27, 2013·Asian Pacific Journal of Tropical Biomedicine·Naveed MuhammadMuzaffer Abass
May 4, 2012·BMC Complementary and Alternative Medicine·Naveed MuhammadHaroon Khan
Mar 28, 2013·BMC Complementary and Alternative Medicine·Naveed MuhammadAnwarul-Hassan Gilani
Apr 8, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Ghias UddinSyed Uzair Ali Shah
Feb 26, 2016·Frontiers in Pharmacology·Sadia PervizAini Pervaiz
Oct 21, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Naveed MuhammadVincenzo De Feo
May 30, 2015·BMC Complementary and Alternative Medicine·Nazar Ul IslamMohammad Raza Shah
Apr 5, 2013·Toxicology and Industrial Health·Haroon KhanNaila Raziq
Dec 17, 2014·Toxicology and Industrial Health·Muhammad NisarFrancesco Maione
Sep 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Komal RizwanRosana Manea
Apr 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Esra Küpeli AkkolEduardo Sobarzo-Sánchez
Jul 15, 2015·Bioorganicheskaia khimiia·A S SokolovaN F Salakhutdinov
Dec 29, 2020·European Journal of Pharmacology·Yusuf Oloruntoyin AyipoThenmoly Damodaran

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