Evaluation of nano hydrogel composite based on gelatin/HA/CS suffused with Asiatic acid/ZnO and CuO nanoparticles for second degree burns

Materials Science & Engineering. C, Materials for Biological Applications
Thanusha A VVeena Koul

Abstract

In the present work, a hydrogel platform composed of biopolymer gelatin, and glycosaminoglycan's (Hyaluronic acid and Chondroitin sulfate) incorporated with Asiatic acid (a triterpenoid) and nanoparticles (Zinc oxide and Copper oxide) has been designed and developed to find out the efficacy of healing in second degree burn wounds in Wistar rats. The developed hydrogel composite has been characterized by physico-chemical methods such as; SEM, swelling, mechanical strength, degradation and drug release kinetics. Results showed that the morphology of composite scaffolds are porous with maximum water uptake capacity of 1068% and possessed tensile strength of ~0.196 MPa. Anti-microbial evaluation depicted increase in zone of inhibition with hydrogel containing gelatin + ZnO (5.3 ± 0.2 mm in E. coli and 4.9 ± 0.6 mm in S. aureus) and gelatin + CuO (4.8 ± 0.7 mm in E. coli, 3.8 ± 0.3 mm in S. aureus) in comparison to hydrogel composite scaffold. In-vitro cytocompatibility of developed hydrogel composite was assessed in terms of MTT and DNA quantification on L929 fibroblast cells. In-vivo studies for the composite scaffolds were evaluated on Wistar rats after second degree burn wounds were induced and studied for 28 days which showed t...Continue Reading

Citations

Jul 12, 2019·Journal of Nanobiotechnology·Wei WangYong-Zhong Du
Oct 20, 2018·Frontiers in Bioengineering and Biotechnology·Giulia SuaratoAthanassia Athanassiou
Oct 19, 2019·IET Nanobiotechnology·Debalina BhattacharyaMainak Mukhopadhyay
Dec 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Roxana GhiulaiCodruţa Şoica
Dec 16, 2020·Journal of Wound Care·Ian Cc King, Parviz Sorooshian
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Karuppusamy ShanmugapriyaHyun Wook Kang
Jan 2, 2021·Materials·Nataliya BabayevskaIgor Iatsunskyi
Oct 23, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Aishwari S Kumar, Kaladhar Kamalasanan
May 4, 2020·Advances in Colloid and Interface Science·Sanjay TiwariPratap Bahadur
May 29, 2021·Biomaterials Science·Yingxia YaoYa Liu
Jul 6, 2021·International Journal of Biological Macromolecules·Ye LiuJianan Ren
Nov 19, 2021·Biomedical Physics & Engineering Express·A V Thanusha, Veena Koul

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