PMID: 11906940Mar 22, 2002Paper

Evaluation of natural killer cell recruitment to embryonic attachment sites during early porcine pregnancy

Biology of Reproduction
Heidi EngelhardtGordon J King

Abstract

Specialized natural killer (NK) lymphocytes are a feature of the pregnant uterus in humans and rodents. Conceptus-mediated recruitment of uterine (u)NK cells in the pig was proposed based on evidence that elevated uNK activity was temporally associated with increased leukocyte density in endometrium underlying conceptuses. The objective of this study was to determine whether uNK cells were more abundant at embryonic attachment sites during the early postattachment period. Mononuclear leukocytes were isolated from endometrium at attachment sites versus between attachment sites, and expression of CD16, a marker for NK cells, was assessed by flow cytometry. CD16 binding was normalized to leukocyte numbers in each sample. CD16+ small lymphocytes were more frequent in uterus than in blood (41% +/- 2% versus 26% +/- 4%). Differences between pregnant and luteal phase uterus (43% +/- 2% versus 31% +/- 7%, respectively) were not statistically significant. In pregnant animals, CD16+ lymphocytes were slightly but significantly more abundant in uterus at attachment sites versus between attachment sites at Days 15-17, 21-22, and 25-28. Before normalization, CD16+ large, granular cells were more abundant at attachment sites versus between at...Continue Reading

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Citations

Jul 10, 2007·The Journal of Reproduction and Development·Chandrakant TayadeBarbara Anne Croy
Jun 17, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Agnieszka Waclawik
Dec 10, 2015·Annual Review of Animal Biosciences·Joan K LunneyGourapura J Renukaradhya
Aug 22, 2008·Immunological Investigations·Nicola F LintonChandrakant Tayade
Nov 14, 2007·American Journal of Reproductive Immunology : AJRI·Jocelyn M WesselsChandrakant Tayade
Mar 17, 2007·American Journal of Reproductive Immunology : AJRI·Tanya DimovaRayna Georgieva
Nov 15, 2006·Immunological Reviews·B Anne CroyChandrakant Tayade
Nov 25, 2005·American Journal of Reproductive Immunology : AJRI·Marianne J van den HeuvelBarbara Anne Croy
Mar 14, 2008·American Journal of Reproductive Immunology : AJRI·Tanya DimovaRayna Georgieva
Jun 25, 2009·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Jennifer L Herington, Brent M Bany
Jul 24, 2004·Animal Reproduction Science·A-M DalinE Persson
Apr 9, 2014·Developmental and Comparative Immunology·K H MairF Meurens
Jan 19, 2015·Journal of Reproductive Immunology·Mallikarjun BidarimathChandrakant Tayade
Jul 1, 2017·Molecular Reproduction and Development·Mallikarjun Bidarimath, Chandrakant Tayade
May 22, 2002·Biology of Reproduction·Heidi EngelhardtGordon J King
Aug 1, 2012·Reproduction in Domestic Animals = Zuchthygiene·A K EdwardsC Tayade
Oct 6, 2020·Frontiers in Immunology·Melissa R StasAndrea Ladinig
May 4, 2021·Frontiers in Veterinary Science·Mallikarjun BidarimathChandrakant Tayade

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