Evaluation of nephroprotective and immunomodulatory activities of antioxidants in combination with cisplatin against murine visceral leishmaniasis.

PLoS Neglected Tropical Diseases
Meenakshi SharmaS Kaur

Abstract

Most available drugs against visceral leishmaniasis are toxic, and growing limitations in available chemotherapeutic strategies due to emerging resistant strains and lack of an effective vaccine against visceral leishmaniasis deepens the crisis. Antineoplastic drugs like miltefosine have in the past been effective against the parasitic infections. An antineoplastic drug, cisplatin (cis-diamminedichloroplatinum II; CDDP), is recognized as a DNA-damaging drug which also induces alteration of cell-cycle in both promastigotes and amastigotes leading to cell death. First in vivo reports from our laboratory revealed the leishmanicidal potential of cisplatin. However, high doses of cisplatin produce impairment of kidney, which can be reduced by the administration of antioxidants. The present study was designed to evaluate the antileishmanial effect of cisplatin at higher doses (5 mg and 2.5 mg/kg body weight) and its combination with different antioxidants (vitamin C, vitamin E and silibinin) so as to eliminate the parasite completely and reduce the toxicity. In addition, various immunological, hematological and biochemical changes induced by it in uninfected and Leishmania donovani infected BALB/c mice were investigated. A significan...Continue Reading

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Citations

Sep 11, 2012·Parasitology Research·Tejinder KaurSukhbir Kaur
Jan 23, 2013·Environmental Toxicology·Yassine ChtourouNajiba Zeghal
Oct 25, 2016·PLoS Neglected Tropical Diseases·Mohammad IslamuddinFarhat Afrin
Dec 25, 2015·PLoS Neglected Tropical Diseases·Elisangela Oliveira FreitasClarisa B Palatnik-de-Sousa

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