Evaluation of new bi-functional terpolymeric nanoparticles for simultaneous in vivo optical imaging and chemotherapy of breast cancer

Drug Delivery and Translational Research
Alireza ShalviriXiao Yu Wu

Abstract

Successful development of a nanoparticulate system for cancer chemotherapy requires detailed knowledge of its biodistribution, clearance and anti-tumour efficacy in vivo. Herein we developed new bi-functional nanoparticles for simultaneous in vivo optical imaging and delivery of the anticancer drug doxorubicin (Dox) for enhanced chemotherapy. Two types of nanoparticles were synthesized, namely preformed nanoparticles (PF-NPs) and self-assembled nanoparticles (SA-NPs). The PF-NPs were prepared by cross-linking graft polymerization of methacrylic acid and polysorbate 80 with starch (PMAA-PS 80-g-St) and then loading the particles with Dox. The SA-NPs were formed upon addition of Dox to non-cross-linked PMAA-PS 80-g-St. A near infrared fluorescent probe was conjugated with the PMAA unit of the nanoparticles. The biodistribution, tumour targeting and pharmacokinetics of the Dox-loaded nanoparticles in mice were determined by in vivo/ex vivo fluorescence imaging and ex vivo fluorescence microscopy. The anti-tumour efficacy of the nanoparticles was investigated using a murine orthotopic breast cancer model. PF-NPs had an average hydrodynamic diameter and zeta potential of 137 ± 3 nm and -38 ± 1 mV, respectively. These values were mea...Continue Reading

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Citations

Jan 29, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alireza ShalviriXiao Yu Wu
Sep 22, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Alireza ShalviriXiao Yu Wu
Apr 25, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Azhar Z AbbasiXiao Yu Wu
May 15, 2021·Drug Metabolism Reviews·Khaled HabasDiana Anderson
Aug 1, 2019·Environmental Science & Technology·Qixing ZhouLu Liu

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