Evaluation of newborn sickle cell screening programme in England: 2010-2016

Archives of Disease in Childhood
Allison StreetlyElizabeth Dormandy

Abstract

To evaluate England's NHS newborn sickle cell screening programme performance in children up to the age of 5 years. Cohort of resident infants with sickle cell disease (SCD) born between 1 September 2010 and 31 August 2015 and followed until August 2016. 1317 infants with SCD were notified to the study from all centres in England and 1313 (99%) were followed up. Early enrolment in clinical follow-up, parental education and routine penicillin prophylaxis. Age seen by a specialist clinician, age at prescription of penicillin prophylaxis and mortality. All but two resident cases of SCD were identified through screening; one baby was enrolled in care after prenatal diagnosis; one baby whose parents refused newborn screening presented symptomatically. There were 1054/1313 (80.3%, 95% CI 78% to 82.4%) SCD cases seen by a specialist by 3 months of age and 1273/1313 (97%, 95% CI 95.9% to 97.8%) by 6 months. The percentage seen by 3 months increased from 77% in 2010 to 85.4% in 2015. 1038/1292 (80.3%, 95% CI 78.1% to 82.5%) were prescribed penicillin by 3 months of age and 1257/1292 (97.3%, 95% CI 96.3% to 98.1%) by 6 months. There were three SCD deaths <5 years caused by invasive pneumococcal disease (IPD) sensitive to penicillin. The ...Continue Reading

References

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Citations

Jan 11, 2020·Haematologica·Emilie DesselasValentine Brousse
Feb 16, 2018·Archives of Disease in Childhood·Lisa M Shook, Russell E Ware
Jan 29, 2019·International Journal of Neonatal Screening·John James, Elizabeth Dormandy
Aug 31, 2019·International Journal of Neonatal Screening·Catherine Coppinger, Robyn O'Loughlin
Feb 12, 2019·International Journal of Neonatal Screening·Yvonne DanielStephan Lobitz
Oct 16, 2020·Haematologica·Emilie DesselasValentine Brousse

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BETA
electrophoresis

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Stata

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