PMID: 2117780Jun 1, 1990Paper

Evaluation of nitrofurantoin on the two stages of urinary bladder carcinogenesis in the rat

Toxicology
R HasegawaS M Cohen

Abstract

The possibility that nitrofurantoin is a complete carcinogen or is an initiator or promoter of urinary bladder carcinogenesis was evaluated in male weanling F344 rats. No increase in tumor incidence was observed in rats fed nitrofurantoin at a level of 0.187% of the diet for 2 years compared to a control group. Also, no evidence of bladder initiating activity by nitrofurantoin was observed using sodium saccharin (5% of the diet) as a promoter, and no promoting activity was observed when nitrofurantoin was fed after initiation by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (0.2% of the diet for 4 weeks). In a second experiment, nitrofurantoin (at a dose of 0.187% of the diet) was administered for 6 weeks to rats with a rapidly proliferating bladder epithelium following freeze ulceration, and then the rats were treated with 5% sodium saccharin in the diet for 98 weeks. In additional rats, labelling index following [3H]thymidine injection, determined after 12 weeks of feeding nitrofurantoin, was not increased above control levels in the urinary bladder, stomach, duodenum, or liver. Metabolism of nitrofurantoin by prostaglandin H synthase (PHS) was examined using solubilized ram seminal vesicle microsomes. The rate of nitrofuranto...Continue Reading

References

Apr 1, 1977·Journal of the National Cancer Institute·C Y WangG T Bryan
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J McCannB N Ames
Mar 1, 1983·Environmental Health Perspectives·S M CohenL B Ellwein
Aug 1, 1982·Toxicology Letters·G MurasakiS M Cohen

❮ Previous
Next ❯

Citations

May 1, 1996·Critical Reviews in Toxicology·S TasD Lison
Feb 2, 2019·International Journal of Environmental Research and Public Health·Chia-Hung HuangChao-Bin Yeh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
W H ButlerM L Sutton
Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
G BorelliP Chieco
Journal of Toxicology and Environmental Health
W T StottF S Cieszlak
© 2021 Meta ULC. All rights reserved