PMID: 6406700Mar 1, 1983Paper

Evaluation of nitrogen utilization in patients receiving total parenteral nutrition

JPEN. Journal of Parenteral and Enteral Nutrition
J M MirtalloR L Ruberg

Abstract

This two phase study evaluates nitrogen utilization by the body as a function of fixed caloric intake but different nitrogen loads. Nitrogen use by the body was estimated from measures of nitrogen balance, net protein utilization, and urea accumulation rate. Phase 1 of this study included 411 measurements of nitrogen use in 120 patients assigned, according to clinical condition, to receive one of the four following therapies: dextrose (D) 25%, amino acids (CAA) 4.25% (Group 1); D 35%, CAA 4.25% (Group 2); D 25%, CAA 21.3% (Group 3); or D 35%, CAA 21.3% (Group 4). Forty patients in Phase 2 were assigned in a randomized, prospective, double blind manner, to receive one of the following regimens; D 35%, CAA 2.75% (Group 5); D 25%, CAA 2.75% (Group 6); D 35%, CAA 4.25% (Group 7); or D 25%, CAA 4.25% (Group 8). In Phase 1, positive nitrogen balance was achieved with the exception of Group 3 where neither the estimated caloric nor nitrogen needs of the patients were met. It appeared that protein utilization was maximal in patients receiving the therapy of highest calorie:nitrogen ratio (Group 4). Phase 2 patients achieved positive nitrogen balance to the same extent (p greater than 0.05) and although net protein utilization improved ...Continue Reading

References

Jan 1, 1977·JPEN. Journal of Parenteral and Enteral Nutrition·G L BlackburnM F Smith
Aug 1, 1979·The American Journal of Clinical Nutrition·D H ElwynJ M Kinney
Jan 4, 1979·The New England Journal of Medicine·A M WoolfsonS P Allison
Nov 1, 1979·JPEN. Journal of Parenteral and Enteral Nutrition·C L LongW S Blakemore
May 1, 1975·The Journal of Surgical Research·P RuttenD Cochran
Jun 1, 1976·The Journal of Surgical Research·B MainiH Y Rienhoff
Jan 1, 1980·Annals of Surgery·H M Shizgal, R A Forse
Nov 1, 1980·Critical Care Medicine·F D HunkerC L Krumdieck

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Citations

May 8, 2007·Nutrition·Carla Barbosa Nonino-BorgesJúlio Sérgio Marchini
Nov 1, 1985·JPEN. Journal of Parenteral and Enteral Nutrition·M B TutenZ Leider
Mar 1, 1985·JPEN. Journal of Parenteral and Enteral Nutrition·J M KosanovichN W Levin
Mar 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·C B GeibigP Tutschka
Jul 1, 1987·Drug Intelligence & Clinical Pharmacy·J M Mirtallo, T Oh
Jul 1, 1984·Drug Intelligence & Clinical Pharmacy·J M Mirtallo, P J Fabri

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