Evaluation of Non-Celiac Gluten Sensitivity in Patients with Previous Diagnosis of Irritable Bowel Syndrome: A Randomized Double-Blind Placebo-Controlled Crossover Trial

Nutrients
Michele BaroneRuggiero Francavilla

Abstract

Background. To date, there is no reliable marker for the diagnosis of non-celiac gluten sensitivity (NCGS), which benefits from a gluten-free diet (GFD). This condition is characterized by functional gastrointestinal symptoms similar to those occurring in the course of irritable bowel syndrome (IBS). However, IBS has a higher prevalence, and often benefits from the administration of a low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet. The overlap of symptoms between these two pathologies has led to an overestimation of self-made diagnosis NCGS. Aims. To better identify NCGS in subjects with a previous diagnosis of IBS. Methods. All subjects received a low FODMAP diet that was also gluten-free (low FODMAP-GFD), and those presenting an improvement of symptoms were exposed to gluten or placebo (double-blind challenge with wash-out and crossover). The response to dietary treatments was evaluated by visual analogue scale (VAS). Results. Of 30 patients (23 women, seven men, aged 42.2 ± 12.5 years, body mass index (BMI ) 24.7 ± 4.1 kg/m2), 26 benefited from the administration of low FODMAP-GFD and were exposed to the gluten/placebo challenge. After the challenge, using an increase of visual ana...Continue Reading

Associated Clinical Trials

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Citations

Oct 18, 2020·Healthcare·Diana Di LibertoMarianna Lauricella
Dec 10, 2020·Nutrients·Maria Raffaella BarbaroGiovanni Barbara
Feb 2, 2021·Gastroenterology Clinics of North America·Kimberly N Harer, Shanti L Eswaran
Mar 27, 2021·The American Journal of Gastroenterology·Jocelyn A SilvesterCiaran P Kelly

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Methods Mentioned

BETA
biopsy

Clinical Trials Mentioned

NCT04017585

Software Mentioned

SPSS
ORGENTEC

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