Evaluation of nongenotoxic and genotoxic factors modulating the frequency of micronucleated erythrocytes in the peripheral blood of mice.

Cell Biology and Toxicology
G SteinheiderH Marquardt

Abstract

The hematological micronucleus test is regarded as an indicator of the clastogenic effect of chemicals and acute cytogenetic damage. The test can be carried out in red blood cells of the bone marrow and of the spleen, as well as in peripheral erythrocytes. We have determined the precise background values of micronucleated red blood cells for the peripheral blood of BALB/c, DBA/2, and NMRI mice. Bleeding, phenylhydrazine-induced hemolysis, and splenectomy generated an increase of micronucleated erythrocytes in the peripheral blood of mice. Our data thus demonstrate that such factors should be taken into consideration when the micronucleus test is used for screening the genotoxic potential of chemicals. Furthermore, the micronucleus-inducing effect of cyclophosphamide was studied in normal and splenectomized mice and, in addition, a comparison of the sensitivity of the micronucleus test was carried out in peripheral blood and bone marrow after cyclophosphamide treatment. Our data demonstrate that the kinetics of micronucleus formation were similar in normal and in splenectomized mice in which the micronucleus levels had returned to normal. The comparison of micronucleus formation in bone marrow and peripheral blood after cyclopho...Continue Reading

References

Feb 1, 1975·Mutation Research·W Schmid
Nov 1, 1976·Mutation Research·P Maier, W Schmid
Jan 1, 1977·Acta Haematologica·I M PannacciulliG V Bogliolo
Oct 22, 1966·Nature·C BiancifioriL Severi
Oct 1, 1967·The Journal of Cell Biology·C F Simpson, J M Kling
Jul 1, 1983·Mutation Research·Y ShindoU Takeda
Jan 1, 1983·Developments in Toxicology and Environmental Science·J T MacGregorC M Wehr
Mar 29, 1958·Nature·G VON EHRENSTEIN, D LOCKNER

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Citations

Mar 1, 1995·Pharmacology & Therapeutics·R E PowersI M Modlin
Nov 1, 1991·Mutation Research·O HiraiH Noguchi
Mar 17, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Gerhard J NohynekHerve Toutain
Apr 7, 2004·Mutation Research·Mauro CristaldiRomano Zilli
Aug 30, 2008·Regulatory Toxicology and Pharmacology : RTP·A VikramG B Jena

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