Evaluation of Nova StatStrip and FreeStyle Precision Pro blood ketone tests using 3-hydroxybutyrate doped samples

Journal of Clinical Laboratory Analysis
Johanna Helmersson-KarlqvistCarolina Backman-Johansson

Abstract

The most clinically useful blood ketone in the diagnosis, management, and recovery of diabetes ketoacidosis in both adults and children is 3-hydroxybutyrate. In the absence of laboratory routine methods, several point-of-care methods are in use, but very few clinical evaluations are published. This study evaluates linearity and reproducibility of two handheld point-of-care meters for blood 3-hydroxybutyrate measurement for hospital use, Nova StatStrip, and FreeStyle Precision Pro. Whole blood from healthy volunteers was spiked with different concentrations of a 3-hydroxybutyrate solution and tested on the point-of-care instruments. The results were compared with plasma 3-hydroxybutyrate that was analyzed with a laboratory enzymatic end point spectrophotometric reference method. Blood 3-hydroxybutyrate on StatStrip was linear with the reference method up to approximately 4 mmol/L, and FreeStyle was linear up to 6 mmol/L. At higher concentrations, the point-of-care instruments gave falsely too low results, especially the StatStrip meter. The FreeStyle meter had better precision and less bias than StatStrip. In the acute setting of diabetes ketoacidosis, blood 3-hydroxybutyrate in the higher ranges should be interpreted with cauti...Continue Reading

References

Mar 25, 1995·Lancet·H E Lebovitz
Jan 15, 2000·Diabetes/metabolism Research and Reviews·L Laffel
Apr 17, 2008·International Journal of Clinical Practice·A RaviP J Twomey
Jul 1, 2009·Diabetes Care·Abbas E KitabchiJoseph N Fisher
Jan 25, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·M W SavageUNKNOWN Joint British Diabetes Societies
May 28, 2011·Diabetes Care·David B SacksUNKNOWN Evidence-Based Laboratory Medicine Committee of the American Association for Clinical Chemistry
Nov 1, 2011·Pediatric Diabetes·Hoi-Ying Elsie YuMark D Kellogg
Jan 22, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·A A KlockerM E Craig
Oct 14, 2014·Diabetic Medicine : a Journal of the British Diabetic Association·S Misra, N S Oliver
Dec 19, 2014·Journal of Diabetes Science and Technology·Ferruccio CeriottiAndrea Mosca

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Citations

Dec 11, 2019·American Journal of Physiology. Endocrinology and Metabolism·Jakob NorgrenMiia Kivipelto

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