Evaluation of novel cationic (99m)Tc-nitrido complexes as radiopharmaceuticals for heart imaging: improving liver clearance with crown ether groups

Nuclear Medicine and Biology
Shuang LiuYoung-Seung Kim

Abstract

This report describes the evaluation of a series of novel cationic (99m)Tc-nitrido complexes, [(99m)TcN(DTC)(PNP)]+ (DTC = crown ether-containing dithiocarbamates; PNP = bisphosphine), as potential radiotracers for myocardial perfusion imaging. Synthesis of cationic (99m)Tc-nitrido complexes was accomplished in two steps according to literature methods. Biodistribution studies were performed in rats. Planar images of Sprague-Dawley rats administered with 15+/-2 MBq of cationic (99m)Tc radiotracer were obtained using a PhoGama large field-of-view Anger camera. Samples from both urine and feces were analyzed by a reversed-phase radio-HPLC method. Results from biodistribution studies showed that most of the cationic (99m)Tc-nitrido complexes have a high initial heart uptake with a long myocardial retention. They also show a rapid clearance from the liver and lungs. Cationic complexes [(99m)TcN(L2)(L6)]+ and [(99m)TcN(L4)(L6)]+ show heart/liver ratios four to five times better than that of (99m)Tc-sestamibi due to their much faster liver clearance. Their heart uptake and heart/liver ratio are comparable to that of (99m)TcN-DBODC5 within the experimental error. These findings have been confirmed by the results from imaging studies. ...Continue Reading

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Citations

May 12, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Lihong BuXiaoyuan Chen
Mar 17, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Young-Seung KimShuang Liu
May 2, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Seth T Dahlberg
Jul 30, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Zhonglin LiuJames M Woolfenden
Aug 5, 2008·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Young-Seung KimShuang Liu
Jul 10, 2007·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Jie LuXuebin Wang
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Apr 2, 2013·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Cristina BolzatiNicola Antonio Colabufo
Jul 30, 2014·Journal of Labelled Compounds & Radiopharmaceuticals·Yumin ZhengShuang Liu
Apr 22, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Leonor MariaIsabel Santos
Jan 17, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Huahui ZengHuabei Zhang
Feb 8, 2019·Current Radiopharmaceuticals·Wei Fang, Shuang Liu
Dec 17, 2010·World Journal of Hepatology·Young-Seung KimShuang Liu
Mar 14, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·Shuang Liu
Jul 18, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Cristina BolzatiGiuliano Bandoli

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