Evaluation of novel insecticides for control of dengue vector Aedes aegypti (Diptera: Culicidae)

Journal of Medical Entomology
Ayesa PaulJeffrey G Scott

Abstract

Insecticides are one of the major tools for controlling vector populations and for reducing the transmission of human pathogens. However, there are few new insecticides being developed and marketed for vector control. Herein, we report on the toxicity of six novel insecticides to both adult and larval Aedes aegypti (L). and the toxicity of three novel insect growth regulators (IGRs) to larvae. Four insecticides were highly or moderately toxic to larvae with LC50 values of 16 (chlorfenapyr), 70 (hydramethylnon), 79 (indoxacarb), and 84 ng/ml (imidacloprid). Diafenthiuron and chlorfenapyr were moderately toxic to adult mosquitoes with LC50 values of 13 and 92 ng/cm2, respectively. Imidacloprid was strongly synergized by piperonyl butoxide (PBO) in Ae. aegypti adults, suggesting that neonicotinoids are intrinsically very toxic to adult mosquitoes (in the absence of detoxification). The effect of PBO on the toxicity in adults and larvae was considerably different, both in terms of the insecticides that were synergized (or antagonized for chlorfenapyr versus adults) and in terms of the degree of synergism. This result implies that the cytochrome P450s involved in metabolism of these insecticides are different between adults and larv...Continue Reading

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Citations

Jan 14, 2016·Parasitology Research·Muhammad Nadir NaqqashMuhammad Salim
Aug 14, 2019·Vector Borne and Zoonotic Diseases·Mohamed Ahmed Ibrahim Ahmed, Aly Abd-Elhameed Othman
Oct 23, 2008·Journal of the American Mosquito Control Association·Emilia SeccaciniHector Masuh
Apr 1, 2011·Asian Pacific Journal of Tropical Biomedicine·Sarita KumarRadhika Warikoo
Apr 21, 2010·Journal of the American Mosquito Control Association·Mark B HertleinScott A Ritchie
Jun 4, 2011·Journal of Vector Ecology : Journal of the Society for Vector Ecology·Sandra A Allan

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