Evaluation of Off-label Prescribing at a Children's Rehabilitation Center

The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG
Kyle E Luedtke, Marcia L Buck

Abstract

This study was developed to evaluate the incidence of off-label prescribing at a pediatric rehabilitation center. Secondary objectives were to describe the medications, patient age groups, and diagnoses most often associated with off-label prescribing. This was a prospective observational study conducted at an academic, inpatient children's rehabilitation center from November 11, 2011, to April 1, 2012. Patients younger than 16 years of age who received at least 1 prescription medication were included. Data were collected from the patients' electronic medical records. A total of 240 medications orders were placed during the study, with 57% written off-label. Thirty-five patients (88%) received at least 1 off-label medication. Forty-nine percent of the orders were for patients younger than the approved range, with 48% written for an unapproved indication, 2% for an alternative route of administration, and 1% for an unapproved age and indication. Children 2 to 12 years of age received 40% of the off-label orders, followed by adolescents with 37%. The therapeutic classes most often prescribed off-label were central nervous system agents and anti-infectives. Off-label prescribing was found in the majority of children receiving reha...Continue Reading

References

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Citations

Nov 30, 2018·Italian Journal of Pediatrics·Lucia De ZenFranca Benini
Aug 28, 2020·Frontiers in Pharmacology·Jean Mendes de Lucena VieiraElisangela da Costa Lima
Jun 1, 2021·Journal of Pediatric Rehabilitation Medicine·Edward Wright, Lauren Fetsko

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