Evaluation of optimal electrode configurations for epidural spinal cord stimulation in cervical spinal cord injured rats

Journal of Neuroscience Methods
Monzurul AlamV Reggie Edgerton

Abstract

Epidural spinal cord stimulation is a promising technique for modulating the level of excitability and reactivation of dormant spinal neuronal circuits after spinal cord injury (SCI). We examined the ability of chronically implanted epidural stimulation electrodes within the cervical spinal cord to (1) directly elicit spinal motor evoked potentials (sMEPs) in forelimb muscles and (2) determine whether these sMEPs can serve as a biomarker of forelimb motor function after SCI. We implanted EMG electrodes in forelimb muscles and epidural stimulation electrodes at C6 and C8 in adult rats. After recovering from a dorsal funiculi crush (C4), rats were tested with different stimulation configurations and current intensities to elicit sMEPs and determined forelimb grip strength. sMEPs were evoked in all muscles tested and their characteristics were dependent on electrode configurations and current intensities. C6(-) stimulation elicited more robust sMEPs than stimulation at C8(-). Stimulating C6 and C8 simultaneously produced better muscle recruitment and higher grip strengths than stimulation at one site. Classical method to select the most optimal stimulation configuration is to empirically test each combination individually for ever...Continue Reading

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Citations

Aug 18, 2017·Physiology·Aiva Ievins, Chet T Moritz
May 21, 2016·Neurorehabilitation and Neural Repair·Daniel C LuYury Gerasimenko
Mar 7, 2019·Neuromodulation : Journal of the International Neuromodulation Society·Jonathan S CalvertKendall H Lee
Dec 10, 2016·Journal of Neural Engineering·Jordan A BorrellRandolph J Nudo
Oct 4, 2020·Acta neurochirurgica·Christopher MarkosianAntonios Mammis
Mar 17, 2018·Experimental and Therapeutic Medicine·Bo-Lun ZhaoLi-Bin An
Jan 10, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Benita JinV Reggie Edgerton
Mar 16, 2021·Dose-response : a Publication of International Hormesis Society·Rakib Uddin AhmedMonzurul Alam
Apr 25, 2021·The Journal of Physiology·Pawan Sharma, Prithvi K Shah
Jul 23, 2021·Scientific Reports·Matthew K HoganPhilip J Horner

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