Evaluation of oral cannabinoid-containing medications for the management of interferon and ribavirin-induced anorexia, nausea and weight loss in patients treated for chronic hepatitis C virus.

Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie
Cecilia T CostiniukCurtis L Cooper

Abstract

The systemic and cognitive side effects of hepatitis C virus (HCV) therapy may be incapacitating, necessitating dose reductions or abandonment of therapy. Oral cannabinoid-containing medications (OCs) ameliorate chemotherapy-induced nausea and vomiting, as well as AIDS wasting syndrome. The efficacy of OCs in managing HCV treatment-related side effects is unknown. All patients who initiated interferon-ribavirin therapy at The Ottawa Hospital Viral Hepatitis Clinic (Ottawa, Ontario) between August 2003 and January 2007 were identified using a computerized clinical database. The baseline characteristics of OC recipients were compared with those of nonrecipients. The treatment-related side effect response to OC was assessed by c2 analysis. The key therapeutic outcomes related to weight, interferon dose reduction and treatment outcomes were assessed by Student's t test and c2 analysis. Twenty-five of 191 patients (13%) initiated OC use. Recipients had similar characteristics to nonrecipients, aside from prior marijuana smoking history (24% versus 10%, respectively; P=0.04). The median time to OC initiation was seven weeks. The most common indications for initiation of OC were anorexia (72%) and nausea (32%). Sixty-four per cent of ...Continue Reading

Citations

Sep 10, 2014·The American Journal of Gastroenterology·Mark E GerichCorey A Siegel
Jun 11, 2015·Journal of Medical Virology·Alireza TahamtanVahid Salimi
Jan 8, 2011·Phytotherapy Research : PTR·Jonathan A FarrimondClaire M Williams
Jun 16, 2012·Pharmacology·Raquel AbaloMaría Isabel Martín-Fontelles
Apr 22, 2015·Addiction Science & Clinical Practice·Katherine A BelendiukMarcel O Bonn-Miller
Jul 12, 2019·Journal of the Canadian Association of Gastroenterology·Christopher N AndrewsStephen E Congly
Jul 17, 2010·Pharmaceuticals·Carol Shoshkes Reiss
Dec 8, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Francis E LotrichPeter Hauser
Aug 17, 2010·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Yuhai ZhangYongyong Xu
Mar 10, 2011·Nature Reviews. Gastroenterology & Hepatology·Mark S SulkowskiOlav Dalgard
Oct 30, 2016·European Journal of Gastroenterology & Hepatology·Hemant GoyalElizabeth May

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