PMID: 9530983Apr 8, 1998Paper

Evaluation of oral mucoadhesive microspheres in man on the basis of the pharmacokinetics of furosemide and riboflavin, compounds with limited gastrointestinal absorption sites

The Journal of Pharmacy and Pharmacology
Y AkiyamaY Ogawa

Abstract

When sustained-release adhesive and non-adhesive microspheres which release the same drugs at similar rates are administered orally, drug absorption after administration of adhesive microspheres should, if the gastrointestinal residence of adhesive microspheres is prolonged as a result of mucoadhesion, be higher than that after administration of non-adhesive microspheres. The gastrointestinal transit of oral adhesive microspheres in man has been evaluated pharmacokinetically using furosemide and riboflavin, compounds with limited absorption sites in the upper small intestine. In a preliminary experiment with fasted rats it was confirmed that a higher percentage of the drug remained in the stomach and that plasma drug levels were higher when furosemide was administered in the form of adhesive rather than non-adhesive microspheres. Two kinds of sustained-release microsphere, adhesive and non-adhesive, containing furosemide and riboflavin in hard gelatin capsules were prepared and orally administered to 10 healthy fasted volunteers in a cross-over design. Areas under the plasma concentration-time curves (AUC) were 1.8 times larger for furosemide and urinary recovery was 2.4 times higher for riboflavin when adhesive microspheres ra...Continue Reading

References

Dec 1, 1978·Journal of Pharmacokinetics and Biopharmaceutics·K YamaokaT Uno
May 1, 1992·The Journal of Pharmacy and Pharmacology·C M LehrH E Junginger
Apr 1, 1990·European Journal of Drug Metabolism and Pharmacokinetics·L M Sanders
Jun 1, 1990·The Journal of Nutrition·H M Middleton
Jan 1, 1987·The Journal of Pharmacy and Pharmacology·R Khosla, S S Davis
Jan 1, 1965·Acta Pharmacologica Et Toxicologica·B Stripp
Mar 1, 1966·Journal of Pharmaceutical Sciences·G Levy, W J Jusko
Dec 1, 1983·Journal of Pharmacokinetics and Biopharmaceutics·M G Lee, W L Chiou

❮ Previous
Next ❯

Citations

Mar 17, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Alexander H Krauland, Andreas Bernkop-Schnürch
Jul 3, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Andreas Bernkop-Schnürch
Aug 13, 2013·International Journal of Biological Macromolecules·Duangkamon SakloetsakunAndreas Bernkop-Schnürch
Sep 4, 2013·International Journal of Pharmaceutics·Sabine HauptsteinAndreas Bernkop-Schnürch
Dec 20, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Andreas Bernkop-SchnürchYvonne Pinter
Oct 22, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·P ArbósJ M Irache
Jun 18, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Eytan A KlausnerAmnon Hoffman
Nov 7, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Andreas Bernkop-SchnürchAlexander H Krauland
Jun 8, 2002·International Journal of Pharmaceutics·B Y ChoiJ B Park
Aug 15, 2002·International Journal of Pharmaceutics·P ArbósJ M Irache
Apr 4, 2003·International Journal of Pharmaceutics·Jaspreet Kaur VasirSanjay Garg
May 20, 2003·International Journal of Pharmaceutics·Yasunori MiyazakiKozo Takayama
May 10, 2001·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·M CuñaD Torres
Apr 27, 2002·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Al-Sayed SallamIbtisam Freij
Jan 20, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Marta RoldoAndreas Bernkop-Schnürch
Feb 15, 2005·Drug Discovery Today·Stanley S Davis
Oct 6, 2009·Chemical & Pharmaceutical Bulletin·Paruvathanahalli Siddalingam Rajinikanth, Brahmeshwar Mishra
May 6, 2014·International Journal of Pharmaceutics·Adeola O Adebisi, Barbara R Conway
Dec 22, 2009·Journal of Drug Targeting·Zeynep Ay SenyigitAndreas Bernkop-Schnürch
Dec 4, 2010·Drug Development and Industrial Pharmacy·Katharina LeithnerAndreas Bernkop-Schnürch
Sep 8, 2010·Journal of Pharmaceutical Sciences·James M Butler, Jennifer B Dressman
May 9, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Andreas Bernkop-Schnürch, Sarah Dünnhaupt
Nov 26, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Kesinee Netsomboon, Andreas Bernkop-Schnürch
Mar 18, 2003·Journal of Clinical Pharmacology·Honghui Zhou
Dec 17, 2014·The Journal of Pharmacy and Pharmacology·Adeola O AdebisiBarbara R Conway
Jan 13, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·P L BardonnetF Falson
Mar 30, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Andreas Bernkop-Schnürch
May 9, 2001·The Journal of Pharmacy and Pharmacology·T TeraoH Shouji
Nov 17, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Juan M IrachePau Arbos
Apr 22, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ehab R Bendas, James W Ayres
Sep 4, 2018·Expert Opinion on Drug Delivery·Forouhe Zahir-JouzdaniAndreas Bernkop-Schnürch
Oct 6, 2012·Chemical & Pharmaceutical Bulletin·Hikaru SugiharaHirofumi Takeuchi
Feb 27, 2004·Immunology and Cell Biology·Bradley J SedgmenShari A Lofthouse
Feb 15, 2012·Journal of Liposome Research·Hikaru SugiharaHirofumi Takeuchi
Oct 3, 2019·Colloids and Surfaces. B, Biointerfaces·Sana SharifMuhammad Yaqoob
Oct 3, 1998·Antimicrobial Agents and Chemotherapy·N NagaharaY Ogawa
Aug 22, 2021·Advanced Drug Delivery Reviews·Sam Maher, David J Brayden
Jan 28, 2020·ACS Applied Materials & Interfaces·Mulazim Hussain AsimAndreas Bernkop-Schnürch

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.