PMID: 15330052Aug 28, 2004Paper

Evaluation of osteoblast-like cell response to Proroot MTA (mineral trioxide aggregate) cement

Journal of Materials Science. Materials in Medicine
G A PelliccioniA Giunti

Abstract

Some endodontic sealers have been shown to cause local and systemic effects, mainly due to microleakage of chemicals from the sealer. To avoid the risk of toxic effects in vivo, the biological compatibility of filling materials has to be assessed. In vitro compatibility of Proroot MTA cement in comparison with two different fillers used in clinical practice, was examined by testing the adherence, viability, proliferation and secretion of collagen of osteoblast-like cells. In our experimental system, Saos-2 cells challenged with Proroot MTA for 24 and 72 h showed a better behaviour than the cells exposed to the other compounds under assay. We found that the cells attached to the rough surface of Proroot MTA cement and spread onto the rough surface. Moreover, the cells on Proroot MTA were viable, grew, and released some collagen even at 72 h, while cell metabolism and growth was dramatically reduced onto sEBA and amalgam surfaces. A parallel behaviour was found after the cells were challenged with extracts of the different fillers. In conclusion, according to our in vitro study, Proroot MTA showed a good interaction with bone-forming cells: such behaviour may partially account for its satisfying clinical performance.

Citations

May 5, 2012·Contemporary Clinical Dentistry·Shiv P MantriCharu A Kapur
Dec 24, 2014·Head & Face Medicine·Susanne JungTill Dammaschke
Mar 26, 2013·Journal of Endodontics·Ji-Youn KangWon-Mann Oh
Apr 24, 2012·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Dan-Åke WälivaaraChrister Dahlin
May 3, 2011·Dental Materials : Official Publication of the Academy of Dental Materials·Maria Giovanna GandolfiCarlo Prati
Jul 21, 2009·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Miranda Deller-Quinn, Hiran Perinpanayagam
Sep 2, 2009·Journal of Endodontics·Chun-Cheng ChenShinn-Jyh Ding
Feb 10, 2009·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Hiran Perinpanayagam, Ebtehal Al-Rabeah
Jan 27, 2009·Journal of Endodontics·Chia-Tze KaoShinn-Jyh Ding
May 19, 2007·Journal of Endodontics·Maria G GandolfiRomano Mongiorgi
Mar 21, 2008·Australian Endodontic Journal : the Journal of the Australian Society of Endodontology Inc·Emre Bodrumlu
Sep 5, 2006·International Endodontic Journal·J Camilleri, T R Pitt Ford
Feb 11, 2015·Dental Materials : Official Publication of the Academy of Dental Materials·Carlo Prati, Maria Giovanna Gandolfi
May 26, 2016·Brazilian Oral Research·Ana Lívia Gomes-CornélioMário Tanomaru
May 3, 2011·Journal of Dental Research·D HashiguchiE Jimi
Sep 7, 2013·Restorative Dentistry & Endodontics·Payal SaxenaVilas Newaskar
Jan 1, 2015·International Scholarly Research Notices·Roberta Bosso-MarteloMario Tanomaru-Filho
Dec 4, 2009·The Journal of Clinical Pediatric Dentistry·Arathi RaoRamya Shenoy

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