Evaluation of OTL38-Generated Tumor-to-Background Ratio in Intraoperative Molecular Imaging-Guided Lung Cancer Resections.

Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
Feredun AzariSunil Singhal

Abstract

Cancer surgery has multiple challenges including localizing small lesions, ensuring negative margins, and identifying synchronous cancers. One of the tools proposed to address these issues is intraoperative molecular imaging (IMI). An important consideration in IMI is the quantification of the tumor fluorescence during the procedure and using that data to add clinical value. Currently, the most commonly cited measure of quantification is the tumor-to-background ratio (TBR). Our goal was to evaluate the clinical value of TBR measured with OTL38 NIR tracer during a lung cancer resection. Intraoperative data was retrospectively reviewed from a prospectively collected 5-year database. Between 2015 and 2020, 279 patients were included in the study. For standardization, all patients underwent infusion of the same targeted molecular optical contrast agent (OTL38) for lung cancer resections; then, the mean fluorescence intensity of the tumors and background tissues were calculated. To evaluate the clinical efficacy of the TBR calculation, the results were correlated with patient, biologic, tumor, and technological factors. For pulmonary surgery, patient factors such as gender, age, smoking history, and time from infusion of OTL38 to su...Continue Reading

References

Jan 1, 1991·Lasers in Surgery and Medicine·J HungB Palcic
Jul 27, 2000·The New England Journal of Medicine·R M PietermanH J Groen
Aug 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John V Frangioni
Aug 1, 2015·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Jane J KeatingSunil Singhal
Mar 10, 2016·International Journal of Cancer. Journal International Du Cancer·Kirstin PirieUNKNOWN Million Women Study Collaborators
Aug 29, 2016·Seminars in Thoracic and Cardiovascular Surgery·Jane Keating, Sunil Singhal
Nov 18, 2017·Annals of Surgical Oncology·Andrew D NewtonSunil Singhal
Dec 16, 2017·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jarrod D PredinaSunil Singhal
Feb 6, 2018·The Annals of Thoracic Surgery·Jarrod D PredinaSunil Singhal
Feb 6, 2018·Molecular Therapy : the Journal of the American Society of Gene Therapy·Stephan RogallaOphir Vermesh
May 31, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Charlotte HoogstinsJacobus Burggraaf
Aug 12, 2018·Journal of Surgical Oncology·Andrew D NewtonSunil Singhal
Sep 13, 2018·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Juliana BuenoJonathan H Chung
Nov 13, 2018·Methods : a Companion to Methods in Enzymology·Joshua B Kelley, Bryce M Paschal
Jan 24, 2019·Journal of Neuro-oncology·Constantinos G HadjipanayisJason P Sheehan
Dec 7, 2019·Journal of Biomedical Optics·John Y K LeeSunil Singhal
Sep 5, 2020·Surgical Oncology Clinics of North America·Feredun AzariSunil Singhal
Nov 23, 2020·The Annals of Thoracic Surgery·Sidhu GangadharanSunil Singhal
May 19, 2021·Journal of Biomedical Optics·Feredun AzariSunil Singhal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.