PMID: 11342007May 9, 2001Paper

Evaluation of oxidative stress during apoptosis and necrosis caused by carbon tetrachloride in rat liver

Biochimica Et Biophysica Acta
F SunS Kojo

Abstract

After 12, 18, and 24 h of oral administration of carbon tetrachloride (as a 1:1 mixture with mineral oil: 4 ml/kg body weight) to rats, the activity of caspase-3-like protease in the liver increased significantly compared to that in the control group that was given mineral oil (4 ml/kg). In plasma, the activity of caspase-3 was barely detectable in the control rat, but increased significantly 24 h after drug administration along with a dramatic increase in glutamate oxaloacetate transaminase. These results indicate that carbon tetrachloride causes apoptosis in the liver by activating caspase-3, which is released to plasma by secondary necrosis. After 18 and 24 h of carbon tetrachloride administration, the liver concentration of hydrophilic vitamin C was decreased significantly, while that of hydrophobic vitamin E was not affected. The plasma concentration of vitamins C and E was not influenced significantly. These results suggest that carbon tetrachloride induces oxidative stress mainly in the aqueous phase of the liver cell.

References

Aug 28, 1979·Biochemical and Biophysical Research Communications·B KalyanaramanR M Philpot
Jul 15, 1979·Biochemical Pharmacology·E K LaiK L Fong
Jul 1, 1989·The Journal of Pathology·D J Pritchard, W H Butler
Mar 1, 1969·The Journal of Pathology·J F Kerr
Dec 16, 1983·Biochemical and Biophysical Research Communications·L R Pohl, J W George
Jan 1, 1984·Methods in Enzymology·J L Buttriss, A T Diplock
Aug 26, 1993·Nature·J OgasawaraS Nagata
Oct 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C Díez-FernándezM Cascales
Feb 1, 1997·Free Radical Research·S TokumaruS Kojo
May 28, 1998·Cell Calcium·P Nicotera, S Orrenius
Aug 26, 1998·Biochimica Et Biophysica Acta·S A SusinG Kroemer
Aug 28, 1998·Bioscience, Biotechnology, and Biochemistry·K IkedaS Kojo
Apr 7, 1999·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·J Krebs
Dec 11, 1999·Biochemical Pharmacology·S HayamiS Kojo

❮ Previous
Next ❯

Citations

Sep 2, 2005·Archives of Toxicology·Xiu An ZhanJian Xin Li
Dec 11, 2008·Archives of Toxicology·Chinatsu IidaShosuke Kojo
Sep 17, 2013·Biological Trace Element Research·Akram EidiShahabeddin Safi
Mar 30, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T FukaoT Ariga
Jul 2, 2003·Toxicology and Applied Pharmacology·Jaspreet S GujralHartmut Jaeschke
Jun 11, 2003·Journal of Gastroenterology and Hepatology·Shinchiro TadaHiromasa Ishii
Jul 13, 2011·International Journal of Molecular Sciences·Yun-Chen TienWen-Huang Peng
Apr 1, 2010·Toxins·Manuel T SilvaAna do Vale
Feb 20, 2014·BioMed Research International·Rumyana SimeonovaMitka Mitcheva
Mar 7, 2008·Apoptosis : an International Journal on Programmed Cell Death·Manuel T SilvaNuno M N dos Santos
Aug 27, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Prasenjit MannaParames C Sil
Oct 1, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Hamid AliSaid Nadeem
May 16, 2012·Biochemical and Biophysical Research Communications·Wei JiangLan Luo
Feb 28, 2016·International Immunopharmacology·Yang LuJingWen Wang
Apr 4, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Akihiko SugiyamaTakashi Takeuchi
Jan 25, 2007·Basic & Clinical Pharmacology & Toxicology·Zhi-Ming WuHao Wu
Apr 18, 2016·Journal of Photochemistry and Photobiology. B, Biology·Amel F M IsmailMamdouh M T Eassawy
Nov 3, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Robert DomitrovićMaja Bival Stefan
Aug 16, 2015·Asian Pacific Journal of Tropical Medicine·El Moataz Bellah El NaggarPavel Suchý
Jul 16, 2015·BMC Complementary and Alternative Medicine·Sanda Vladimir-KneževićRobert Domitrović
Jun 13, 2012·Biological & Pharmaceutical Bulletin·Kaori KisoShosuke Kojo
Apr 28, 2006·The Journal of Pharmacy and Pharmacology·Tzung-Yan LeeHan-Chieh Lin
Nov 20, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·In-Chul LeeJong-Choon Kim
Jan 3, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Shuai ZhangJinyong Peng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis