PMID: 3556193Jan 1, 1987Paper

Evaluation of oxprenolol slow release and osmotic release by exercise testing and ambulatory electrocardiographic monitoring in patients with chronic stable angina pectoris

European Journal of Clinical Pharmacology
M J BowlesE B Raftery

Abstract

We have treated eleven patients with chronic stable angina pectoris with slow-release oxprenolol (160 mg and 320 mg) in a double-blind crossover study and evaluated its efficacy objectively by exercise testing between 180 and 240 min after dosing. The mean exercise time increased significantly from 6.2 min on placebo to 7.2 min and 7.3 min on oxprenolol 160 mg and 320 mg respectively. No overall beneficial effects could be demonstrated for the higher dose. A further 20 patients received slow release oxprenolol 160 mg and 10/170 mg "Oros" (osmotic release) oxprenolol in a double-blind crossover study using exercise testing and ambulatory electrocardiographic monitoring at 21-23 h after dosing. The mean exercise time increased significantly from 7.0 min on placebo to 8.3 min on slow-release oxprenolol and to 8.1 min on "Oros" oxprenolol. The effects of the 2 treatments on exercise and ambulatory heart rates were comparable. Two patients were withdrawn during the double-blind treatment period while receiving oxprenolol slow-release, one because of unstable angina and another because of throbbing headache. These findings confirm that slow-release oxprenolol is effective in treating chronic stable angina pectoris at the 160-mg dose....Continue Reading

References

Dec 1, 1975·Journal of Pharmaceutical Sciences·F Theeuwes
May 1, 1977·Clinical Pharmacology and Therapeutics·D G McDevittR G Shanks
Jan 1, 1979·Journal of Clinical Pharmacology·I GavrasH R Brunner
Mar 1, 1976·Clinical Pharmacology and Therapeutics·B J MatersonE C Perez-Stable
Jun 1, 1976·British Journal of Clinical Pharmacology·M J WestE B Faragher
Jan 20, 1973·British Medical Journal·U ThadaniS H Taylor
Aug 2, 1973·The New England Journal of Medicine·B Blackwell
Aug 1, 1984·International Journal of Cardiology·N S KhurmiE B Raftery
Jan 1, 1983·European Journal of Clinical Pharmacology·M W Millar-CraigE B Raftery
Jun 1, 1980·Clinical Pharmacology and Therapeutics·J FerlinzW S Aronow
Oct 1, 1980·British Heart Journal·V BalasubramanianE B Raftery

Related Concepts

Angina Pectoris
Clinical Trials
Controlled-Release Preparations
Double-Blind Method
Electrocardiographic Recorders
Cardiopulmonary Exercise Test
Pulse Rate
Osmolality
Trasicor
Randomization

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