Evaluation of P-glycoprotein (Pgp) expression in human osteosarcoma by high-throughput tissue microarray

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Yan GaoZhenfeng Duan

Abstract

Survival of osteosarcoma patients is currently limited by the development of metastases and multidrug resistance (MDR). A well-established cause of MDR involves overexpression of P-glycoprotein (Pgp) in tumor cells. However, some discrepancies still exist as to the clinical significance of Pgp in osteosarcoma. We sought to elucidate further whether the Pgp expression correlated with clinical behavior in a series of patients with osteosarcoma via high-throughput tissue microarray (TMA) analysis. Immunohistochemical analysis of Pgp expression in a TMA of 114 specimens with a retrospective review of 70 osteosarcoma patients admitted to the Massachusetts General Hospital (MGH) was performed. High Pgp expression was correlated with metastasis development and poor response to pre-operative chemotherapy in osteosarcoma patients. Eighteen of the fifty-seven patients initially admitted with primary osteosarcoma showed high Pgp expression. Among these 18 patients with high Pgp expression, 13 of 18 (72%) patients eventually developed metastases. There was no significant clinical relevance between Pgp expression and osteosarcoma survival. These results support that high expression of Pgp is important, but cannot be assigned as, an individu...Continue Reading

References

Apr 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H S ChanV Ling
Nov 23, 1995·The New England Journal of Medicine·N BaldiniM Campanacci
Jan 1, 1993·Breast Cancer Research and Treatment·E HennequinJ C Jardillier
Aug 1, 1997·Pediatric Clinics of North America·P A Meyers, R Gorlick
Dec 9, 1997·Journal of the National Cancer Institute·H S ChanV Ling
Jul 14, 1998·Nature Medicine·J KononenO P Kallioniemi
Jul 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P A MeyersJ H Healey
Jul 15, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J S WunderI L Andrulis
Feb 23, 2002·The American Journal of Surgical Pathology·Mark A RubinKenneth J Pienta
Mar 21, 2002·Nature Reviews. Cancer·Michael M GottesmanSusan E Bates
Oct 25, 2003·Oncogene·Suresh V AmbudkarMichael M Gottesman
Mar 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul A MeyersHolcombe Grier
Jul 13, 2006·Expert Review of Anticancer Therapy·Alexander J Chou, Richard Gorlick
May 22, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cindy L SchwartzUNKNOWN Children's Oncology Group
Aug 30, 2008·Paediatric Drugs·Alexander J ChouRichard Gorlick
Aug 13, 2009·Expert Review of Anticancer Therapy·Paul A Meyers
Dec 2, 2009·Methods in Molecular Biology·Jean-Pierre Gillet, Michael M Gottesman
Mar 10, 2010·Cancer Treatment and Research·Giulia Ottaviani, Norman Jaffe
Jun 2, 2010·Journal of Cancer Research and Clinical Oncology·Muhammad Umar JawadSean P Scully
Jun 10, 2010·Cancer Research·François-Xavier DieudonnéDominique Modrowski
Aug 10, 2010·Expert Opinion on Emerging Drugs·Claudia Maria HattingerMassimo Serra
Feb 3, 2012·Journal of Comparative Pathology·T S Osborne, C Khanna

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Citations

Sep 24, 2020·International Journal of Molecular Sciences·Ingrid Lilienthal, Nikolas Herold
Sep 10, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Juncheng CuiZhenfeng Duan
Jun 10, 2021·Therapeutic Advances in Musculoskeletal Disease·Hangzhan MaZhenfeng Duan

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