Evaluation of p40 as a Myoepithelial Marker in Different Breast Lesions

Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology
Bence KőváriGábor Cserni

Abstract

The identification of myoepithelial cells (MEC) is a valuable clue in the differential diagnosis of breast lesions. A series of breast lesions with occasional absence of or decrease in the staining for some MEC markers was analyzed for the expression of a novel marker, p40, and results were compared to the p63 staining profile. Samples (n = 34) from patients with benign sclerosing lesions (n = 11), ductal carcinoma in situ (n = 13) and adenomyoepithelial lesions (n = 10) and associated normal breast tissues (n = 31) were selected to evaluate the differential expression of p40 and p63 using immunohistochemistry. Triple-negative, cytokeratin 5 (CK5)-expressing invasive breast carcinomas (n = 19) were also assessed for p40 expression. Normal structures showed similar diffuse and strong MEC positivity using p40 and p63 in all 31 cases. The two antibodies performed similarly in all 34 breast lesions acknowledged to present altered expression of MEC markers; focal losses of expression occurred in a parallel fashion. CK5-positive carcinomas expressed p40 more frequently than p63 (18/19 vs. 8/19) and the staining was more marked. It seems that both antibodies can be used interchangeably for MEC identification, but show differences in t...Continue Reading

Citations

Jan 29, 2016·Virchows Archiv : an International Journal of Pathology·G CserniS Bianchi
May 27, 2017·Applied Immunohistochemistry & Molecular Morphology : AIMM·Laila KhazaiMarilin Rosa
Jun 27, 2019·International Journal of Surgical Pathology·Rui GuoJun Yang

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