Evaluation of Pankrin, a new serum test for diagnosis of acute pancreatitis

Clinica Chimica Acta; International Journal of Clinical Chemistry
Volker KeimJoachim Mossner

Abstract

Evaluation of a new serum test for diagnosis of acute pancreatitis. One hundred and sixty-three patients presenting with acute abdominal pain were included into the study. Acute pancreatitis was diagnosed by CT or ultrasound. Serum samples were taken 0-1 days, 2-3 days, and 4-5 days after onset of symptoms and C-reactive protein, lipase, elastase, and amylase were determined. As a further parameter, Pankrin, a newly available kit for the measurement of a mixture of elastase and other pancreatic secretory proteins was used. As control, serum from 558 apparently healthy blood donors was analysed. The receiver operator characteristics (ROC) and the areas under the curves (AUC) were calculated for each individual test. In Western blot analysis the antibodies of the Pankrin assay detected the majority of protein bands in human pancreatic juice. In blood donors, the median value of Pankrin was 88 U/ml (range 14-316 U/ml). In 16 from 163 patients with acute abdominal pain, acute pancreatitis was diagnosed and the median Pankrin level in samples collected on days 0-1 was 345 U/ml (range 220-518 U/ml, p<0.0001). In those patients with abdominal pain but without pancreatitis, the median was 116 U/ml (range 17-396 U/ml). The ROC-curves fo...Continue Reading

References

Jun 30, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·P K BuamahA W Skillen
Jan 1, 1987·Scandinavian Journal of Gastroenterology. Supplement·G FenyöH Wilczek
Nov 17, 1986·Klinische Wochenschrift·M BüchlerH G Beger
Sep 1, 1993·American Journal of Surgery·S T FanJ Wong

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Citations

Apr 22, 2017·The Cochrane Database of Systematic Reviews·Gianluca RompianesiKurinchi Selvan Gurusamy
Aug 23, 2005·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·N Alexakis, J P Neoptolemos

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