Evaluation of parameters involved in preparation and release of drug loaded in crosslinked matrices of alginate

Journal of Controlled Release : Official Journal of the Controlled Release Society
S Al-MusaA A Badwan


Parameters affecting the characteristics of the drug loaded crosslinked sodium alginate matrix films and the release of metoclopramide hydrochloride and cisapride from these matrices were studied. It was shown that the release rate is influenced by the crosslinking technique of the matrix film, crosslinker type and concentration, drug physico-chemical properties especially solubility and the molecular weight, acidity of the release medium, concentration and the loaded quantity of the drug in the matrix. The crosslinking process of the matrix film was shown to be an interfacial phenomenon and the nature of crosslinking depends on the crosslinker type and concentration. This work also showed that crosslinked alginate in a matrix form has limitation in practical use due to the effect of acidic medium on the crosslinking of the matrix film and hence, the rate of drug release.


Sep 1, 1993·Journal of Pharmaceutical Sciences·M RajaonarivonyP Couvreur

❮ Previous
Next ❯


Feb 23, 2012·Journal of Materials Science. Materials in Medicine·Nophawan ParadeeWalaiporn Prissanaroon-Ouajai
Apr 16, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sinjan De, Dennis Robinson
Feb 13, 2001·International Journal of Pharmaceutics·X Z ShuW Song
Jan 31, 2013·Analytical Chemistry·Mariana B Oliveira, João F Mano
Oct 17, 2013·ACS Applied Materials & Interfaces·Can Hui YangZhigang Suo
May 9, 2013·Journal of Biomaterials Science. Polymer Edition·Lihong FanTan Wang
Mar 5, 2014·Drug Development and Industrial Pharmacy·Huiming JiangLiangke Zhang
Aug 2, 2002·Drug Development and Industrial Pharmacy·Hanne Hjorth Tønnesen, Jan Karlsen
Nov 9, 2001·Drug Development and Industrial Pharmacy·M C LamasR Firenstein
Oct 1, 2015·Drug Development and Industrial Pharmacy·Yanhua LiuWenping Wang
Feb 15, 2003·Journal of Pharmaceutical Sciences·Nikhil O Dhoot, Margaret A Wheatley
Jan 7, 2015·ACS Applied Materials & Interfaces·Wen Jiang ZhengYong Mei Chen
Jun 26, 2007·Chemosphere·F Flores CéspedesM Fernández Pérez
Feb 3, 2007·Journal of Biomedical Materials Research. Part a·Qun WangYumin Du
Feb 11, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Rubina P ShaikhRiaz A Khan
Mar 13, 2014·Journal of Food Science·B Allison HarperMassimo F Marcone
Jun 24, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·P Ferreira Almeida, A J Almeida
Jul 1, 2014·International Journal of Pharmaceutics·Yazmin J CrossinghamRoss A Kennedy
Oct 12, 2000·Drug Development and Industrial Pharmacy·A R KulkarniW E Rudzinski
Aug 12, 2014·Drug Development and Industrial Pharmacy·Dharmendra Jain, Daniel Bar-Shalom
Mar 2, 2005·Drug Delivery·J BalasubramaniamShri Kant
May 18, 2012·Pharmaceutical Development and Technology·Shivaan CooppanViness Pillay
May 16, 2015·Critical Reviews in Food Science and Nutrition·Su Hung ChingBhesh Bhandari
Dec 12, 2012·Carbohydrate Polymers·Ji Sheng YangWen He
Aug 16, 2016·Progress in Biomaterials·Nachiket PatelJerry Nesamony
Mar 11, 2009·Journal of Hazardous Materials·F J Garrido-HerreraM Fernández-Pérez
May 25, 2006·Drug Development and Industrial Pharmacy·P SmrdelA Mrhar
Oct 10, 2006·Journal of Biomaterials Science. Polymer Edition·M TafaghodiM R Jaafari
Nov 17, 2017·Journal of Biomaterials Applications·Wanar KongkaewAnuvat Sirivat
Mar 26, 2011·Biomedical Materials·Aparna JejurikarLisbeth Grøndahl
Aug 21, 2020·Macromolecular Rapid Communications·Jun Kit WangChor Yong Tay
May 23, 2008·Biomacromolecules·Fengyi LiuFrançoise Quignard

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.