PMID: 3215109Sep 1, 1988Paper

Evaluation of passively absorbed saliva for determination of oral slow-release theophylline bioavailability in children

Drug Intelligence & Clinical Pharmacy
L VaughanJ G Merrick

Abstract

Assessment in young children of the bioavailability of slow-release theophylline formulations is hampered by the requirement for frequent blood sampling. Calculations of bioavailability from serial serum and passively absorbed saliva samples were therefore compared in six 9- to 12-year-old asthmatic children receiving multiple doses of Theo-Dur Sprinkle every 12 hours, using Theo-Dur tablets, a previously characterized formulation, as a reference. Results indicated 85 +/- 5 percent and 82 +/- 8 percent (mean +/- SEM) relative bioavailability based on serum and salivary measurements, respectively. Correlation coefficient for serum and passively absorbed saliva bioavailabilities was 0.90. Passively absorbed saliva provides an acceptably accurate, noninvasive method for theophylline bioavailability assessment and may be a useful alternative for bioavailability studies in young children.

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Citations

Mar 1, 1992·The Annals of Pharmacotherapy·R L Cody, M K Slack
Sep 20, 1993·Annals of the New York Academy of Sciences·J T Wilson
Jun 29, 2006·The Annals of Pharmacotherapy·H William Kelly
Mar 1, 1993·The American Review of Respiratory Disease·W E HoldenJ H Fitchen

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