Evaluation of patients with diseases of the prostate using prostate-specific antigen density

British Journal of Urology
J M WolffG Jakse

Abstract

To compare the efficacy of two tests, prostatic-specific antigen (PSA) and the PSA/prostate volume ratio (PSAD), as diagnostic and staging markers to discriminate patients with benign prostatic hyperplasia (BPH) from patients with cancer of the prostate (CaP). Prostate gland volumes were estimated in 60 patients with BPH and 88 patients with clinically organ-confined CaP by performing transrectal ultrasonography (TRUS) and using the prolate ellipse formula. Serum PSA concentration was determined using an enzyme immunoassay. In patients with BPH, the prostates were removed either by transurethral resection or retropubic prostatectomy. Patients with CaP underwent laparoscopic pelvic lymphadenectomy followed by radical perineal prostatectomy. PSAD was calculated by relating the serum PSA level to the TRUS-estimated prostate volume. The median PSA level was 4.4 ng/mL in patients with BPH, 9.3 ng/mL in patients with CaP-NO disease and 24 ng/mL in those with CaP-N+ disease. However, imposing a PSA limit of 4 ng/mL for the diagnosis of CaP gave a positive predictive value of only 64.8%, whereas a limit of 10 ng/mL gave a positive predictive value of 71.4%. In contrast, the median PSAD was 0.086 ng/mL/cm3 in patients with BPH, but was ...Continue Reading

References

Oct 1, 1991·Current Opinion in Immunology
Jan 1, 1991·CA: a Cancer Journal for Clinicians·C C BoringT Tong
Jan 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·O M JensenH Renard
Oct 8, 1987·The New England Journal of Medicine·T A StameyE Redwine
Oct 1, 1989·The Journal of Urology·M A HudsonW J Catalona
Dec 1, 1989·American Journal of Clinical Pathology·M K BrawerJ A Gaines
Jun 1, 1993·Disease Markers·J H Howanitz
May 23, 2013·International Journal of Urology : Official Journal of the Japanese Urological Association·Tokunori Yamamoto

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Citations

Oct 11, 2005·Der Pathologe·D C VerghoJ M Wolff
Oct 21, 2010·Der Urologe. Ausg. A·C BörgermannH Rübben
May 1, 1997·The Urologic Clinics of North America·M C Beduschi, J E Oesterling
Nov 29, 2005·Critical Reviews in Oncology/hematology·Sergio BracardaGeorg Bartsch

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