Evaluation of pharmacokinetic interactions after oral administration of mycophenolate mofetil and valaciclovir or aciclovir to healthy subjects

Clinical Pharmacokinetics
François GimenezEric Singlas

Abstract

To investigate a potential pharmacokinetic interaction between mycophenolate mofetil (MMF) and aciclovir or valaciclovir. Fifteen healthy subjects were enrolled in a prospective, randomised, open-label, single-dose, cross-over study conducted at a single centre. Subjects received each of the following five oral treatments: (i) aciclovir 800 mg alone; (ii) valaciclovir 2 g alone; (iii) MMF 1 g alone; (iv) valaciclovir 2 g + MMF 1 g; and (v) aciclovir 800 mg + MMF 1 g. The following pharmacokinetic parameters were estimated for aciclovir, mycophenolic acid (MPA) and its inactive glucuronide metabolite (MPAG) from the plasma concentration-time data using noncompartmental methods: area under the concentration-time curve from zero to infinity (AUC infinity), terminal elimination half-life (t1/2z), peak concentration (Cmax) and time to Cmax (tmax). The renal clearance (CLR) of aciclovir was also calculated. These parameters were compared when aciclovir or valaciclovir were coadministered with MMF relative to aciclovir, valaciclovir or MMF given alone. Aciclovir Cmax, tmax and AUC infinity were significantly increased by 40%, 0.38 hour and 31%, respectively, following coadministration of aciclovir and MMF, whereas aciclovir t1/2z was ...Continue Reading

References

Jan 1, 1989·Clinical Pharmacokinetics·C A van Ginneken, F G Russel
Mar 27, 2001·Transplantation Proceedings·J F CailhierR Dandavino

❮ Previous
Next ❯

Citations

Mar 3, 2007·Biological & Pharmaceutical Bulletin·Masayuki NadaiTakaaki Hasegawa
Jan 5, 2007·Clinical Pharmacokinetics·Christine E Staatz, Susan E Tett
Jul 26, 2006·Expert Opinion on Drug Metabolism & Toxicology·Jasminder Sahi
Jul 26, 2006·Expert Opinion on Drug Metabolism & Toxicology·Maria ShipkovaEberhard Wieland
Mar 28, 2007·Journal of Pharmaceutical Sciences·Kyle A FliszarNatalie Foster
May 9, 2012·Immunology and Allergy Clinics of North America·Marina Eskin-SchwartzDaniel Mimouni
Sep 20, 2011·Dermatologic Clinics·Marina Eskin-SchwartzDaniel Mimouni
Nov 2, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T ReischigV Treska
Jul 19, 2005·Medicina clínica·Amaro GarcíaJose-Vicente Torregrosa
Apr 5, 2005·Lupus·M Hartmann, A Enk
Sep 26, 2014·Expert Review of Pharmacoeconomics & Outcomes Research·Tomas Reischig, Martin Kacer
Nov 1, 2007·Dermatologic Therapy·Jeffrey Zwerner, David Fiorentino
Dec 10, 2019·Journal of Clinical Pharmacology·Juthipong BenjanuwattraNut Koonrungsesomboon
Aug 28, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Laneshia Karee TagueAndrew E Gelman
Feb 18, 2017·Clinical Pharmacokinetics·Anton IvanyukThierry Buclin
Jan 13, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Vincent DasChristophe Legendre
May 24, 2021·Gastroenterología y hepatología·Ahamd RashidiMaryam Moini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Dennis A HesselinkTeun van Gelder
© 2022 Meta ULC. All rights reserved