Abstract
To investigate a potential pharmacokinetic interaction between mycophenolate mofetil (MMF) and aciclovir or valaciclovir. Fifteen healthy subjects were enrolled in a prospective, randomised, open-label, single-dose, cross-over study conducted at a single centre. Subjects received each of the following five oral treatments: (i) aciclovir 800 mg alone; (ii) valaciclovir 2 g alone; (iii) MMF 1 g alone; (iv) valaciclovir 2 g + MMF 1 g; and (v) aciclovir 800 mg + MMF 1 g. The following pharmacokinetic parameters were estimated for aciclovir, mycophenolic acid (MPA) and its inactive glucuronide metabolite (MPAG) from the plasma concentration-time data using noncompartmental methods: area under the concentration-time curve from zero to infinity (AUC infinity), terminal elimination half-life (t1/2z), peak concentration (Cmax) and time to Cmax (tmax). The renal clearance (CLR) of aciclovir was also calculated. These parameters were compared when aciclovir or valaciclovir were coadministered with MMF relative to aciclovir, valaciclovir or MMF given alone. Aciclovir Cmax, tmax and AUC infinity were significantly increased by 40%, 0.38 hour and 31%, respectively, following coadministration of aciclovir and MMF, whereas aciclovir t1/2z was ...Continue Reading
Citations
May 6, 2009·Antimicrobial Agents and Chemotherapy·L ZengA J McLachlan
Mar 3, 2007·Biological & Pharmaceutical Bulletin·Masayuki NadaiTakaaki Hasegawa
Jan 5, 2007·Clinical Pharmacokinetics·Christine E Staatz, Susan E Tett
Jul 26, 2006·Expert Opinion on Drug Metabolism & Toxicology·Jasminder Sahi
Jul 26, 2006·Expert Opinion on Drug Metabolism & Toxicology·Maria ShipkovaEberhard Wieland
Mar 28, 2007·Journal of Pharmaceutical Sciences·Kyle A FliszarNatalie Foster
May 9, 2012·Immunology and Allergy Clinics of North America·Marina Eskin-SchwartzDaniel Mimouni
Sep 20, 2011·Dermatologic Clinics·Marina Eskin-SchwartzDaniel Mimouni
Apr 28, 2007·Biochemical Pharmacology·Yuichi UwaiKen-ichi Inui
May 20, 2009·Journal of Clinical Pharmacology·Takafumi NaitoJunichi Kawakami
Sep 29, 2009·Journal of Clinical Pharmacology·Korbinian RupprechtLothar Faerber
Nov 2, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T ReischigV Treska
Jul 19, 2005·Medicina clínica·Amaro GarcíaJose-Vicente Torregrosa
Apr 4, 2017·Journal of Clinical Pharmacy and Therapeutics·W A WatsonM H Scheetz
Apr 5, 2005·Lupus·M Hartmann, A Enk
Sep 26, 2014·Expert Review of Pharmacoeconomics & Outcomes Research·Tomas Reischig, Martin Kacer
Nov 1, 2007·Dermatologic Therapy·Jeffrey Zwerner, David Fiorentino
Sep 16, 2010·British Journal of Clinical Pharmacology·Lihua ZengAndrew J McLachlan
Dec 10, 2019·Journal of Clinical Pharmacology·Juthipong BenjanuwattraNut Koonrungsesomboon
Aug 28, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Laneshia Karee TagueAndrew E Gelman
Jan 29, 2008·Therapeutic Drug Monitoring·Masatomo MiuraTomonori Habuchi
Feb 18, 2017·Clinical Pharmacokinetics·Anton IvanyukThierry Buclin
Jan 13, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Vincent DasChristophe Legendre
Jun 3, 2017·Rheumatology·Matthew CatesJames Galloway
May 24, 2021·Gastroenterología y hepatología·Ahamd RashidiMaryam Moini