Evaluation of phenobarbital/beta-naphthoflavone as an alternative S9-induction regime to Aroclor 1254 in the rat for use in in vitro genotoxicity assays

Mutagenesis
R D CallanderB M Elliott

Abstract

A series of bacterial mutation, mammalian cell (L5178Y) gene mutation and in vitro cytogenetic assays were performed to compare the efficacy of using S9 fractions prepared from rats induced with a combination of phenobarbital (PB) and beta-naphthoflavone (beta NF), with S9 fractions from rats treated with the general enzyme inducer Aroclor 1254. Although some quantitative differences in the magnitudes of the mutagenic/clastogenic effects were observed between the two induction regimes, no qualitative differences were observed. The use of a combined PB/beta NF induction regime using oral dosing is therefore considered to be a suitable substitute for Aroclor 1254.

Citations

Jan 22, 1998·Mutation Research·J AshbyJ Williamson
Mar 29, 2003·Regulatory Toxicology and Pharmacology : RTP·Atsushi HakuraTetsuo Satoh
Aug 17, 2002·Journal of Pharmacological and Toxicological Methods·A HakuraT Satoh
Aug 26, 1998·Mutation Research·B M ElliottJ Ashby
Mar 5, 2011·Journal of Agricultural and Food Chemistry·Kuo-Hui LinJen-Kun Lin
Jan 19, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Leslie RecioGregory L Kedderis
Oct 28, 1999·Drug and Chemical Toxicology·E V SargentB D Naumann
Dec 6, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Gianni Dal NegroDavide Sciuscio
Feb 27, 2018·Environmental and Molecular Mutagenesis·Krista L DoboMichelle O Kenyon
Sep 21, 2011·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Shams TabrezMasood Ahmad
Apr 22, 2005·Mutagenesis·Atsushi HakuraTetsuo Satoh
Sep 30, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Chad DeisenrothRussell S Thomas

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