Evaluation of placental function using near infrared spectroscopy during fetal growth restriction

Journal of Perinatal Medicine
Junichi HasegawaTakashi Okai

Abstract

To investigate whether a near infrared spectroscopy (NIRS) system is useful for evaluation of the placental function in cases of fetal growth restriction (FGR). Subjects included 282 delivered neonates of appropriate for gestational age (AGA) and 44 small for gestational age (SGA) babies. The measurement of the concentration of oxyhemoglobin (HbO(2)) and deoxyhemoglobin (HHb) was conducted using transabdominal NIRS targeting the placenta at around 20 weeks, 30 weeks and after 36 weeks of gestation and calculated tissue oxygen indexes (TOI=HbO(2)/total Hb). We correlated between TOIs and causes of FGR. TOIs measured immediately before delivery in the SGA group with severe pre-eclampsia (79.2+/-3.8 (%+/-standard deviation (SD); P=0.002)) and placental abnormalities (78.2+/-3.6; P=0.043) were higher than in the AGA group (74.0+/-4.5). TOIs in the SGA group with umbilical cord abnormalities were lower (69.7+/-7.7; P=0.024) than in the AGA group. NIRS might provide information about blood oxygen level of the intervillous space and thus explain the cause of FGR.

References

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Jul 30, 2005·Seminars in Thrombosis and Hemostasis·Jun KakogawaNaohiro Kanayama
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Citations

Jan 22, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Valentina BozzettiPaolo E Tagliabue
Sep 4, 2013·Congenital Anomalies·Angus L ActonDavid S McKenna
May 15, 2012·Reproductive Sciences·Ercan Bastu, John Yeh
Jun 8, 2018·Journal of Clinical Monitoring and Computing·Kiguna SeiMiya Ishihara
Apr 7, 2019·Nature Protocols·Camilo L M MoraisFrancis L Martin
Jan 26, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Shoichi MagawaTomoaki Ikeda
Aug 31, 2021·Biomedical Optics Express·Thien NguyenAmir H Gandjbakhche
Apr 14, 2017·Journal of Gynecology Obstetrics and Human Reproduction·C GarabedianV Houfflin-Debarge

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