Evaluation of plasma microRNA expressions in patients with juvenile idiopathic arthritis

Clinical Rheumatology
Ferhat DemirMukaddes Kalyoncu

Abstract

Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease of childhood, yet its etiology is unknown. It is known that microribonucleic acids (miRNAs) play a role in immunoregulation. We aimed to evaluate the plasma expression of some candidate miRNAs that are associated with the pathogenesis of autoimmunity. Thirty-one patients diagnosed with JIA and age-sex-matched 31 healthy children were enrolled for the study. The plasma levels of four candidate miRNAs (miRNA-16, miRNA-155, miRNA-204, and miRNA-451), which are known to be associated with autoimmunity, were examined in all the subjects. The plasma levels of miRNAs were measured with real-time PCR in the patients in active and inactive periods and in the healthy controls. The groups were compared with each other. The plasma miRNA-155 levels were found to increase in the JIA patients compared to the healthy controls, and it was statistically more significant in the inactive period. We found that the JIA patients had the higher levels of miRNA-16 and the lower levels of miRNA-204/miRNA-451 expressions compare with the control group, but there was no statistically significant difference. A statistically significant decrease in the plasma levels of miRNA-20...Continue Reading

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Citations

May 31, 2019·Current Opinion in Rheumatology·Amandine Charras, Christian M Hedrich
Oct 2, 2019·Frontiers in Immunology·Xiaoling Niu, Grant S Schulert
Oct 11, 2020·Clinical Rheumatology·Alper Han CebiMukaddes Kalyoncu
Jul 10, 2021·Pediatric Research·Jennifer Bermick, Matthew Schaller
Aug 17, 2021·Expert Review of Clinical Immunology·Davide SelvestrelGiuliana Decorti

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