PMID: 15374203Nov 1, 1995Paper

Evaluation of platelet hyperfunction in aged subjects using spontaneous platelet aggregation in whole blood

Archives of Gerontology and Geriatrics
A SuehiroE Kakishitaa

Abstract

To evaluate the changes in platelet function in connection with aging, spontaneous platelet aggregation in whole blood (SPAWB) from healthy aged people was measured and compared to that in the whole blood of young subjects as well as patients with old cerebral infarction. SPAWB was determined by the fall in non-aggregated single platelet count by stirring without adding platelet aggregating agents to whole blood. SPAWB in the aged subjects was significantly higher than that in the young volunteers. In patients with old cerebral infarction taking no platelet suppressive agents, SPAWB was also high but was suppressed to the level of that in young subjects by prescription of ticlopidine. Although when aspirin or a mixture of phosphocreatine and creatine phosphokinase (CP/CPK) was added in vitro to whole blood obtained from the aged subjects, SPAWB was inhibited to 50%, addition of the specific PAF (platelet activating factor) inhibitor TCV-309 induced only partial inhibition of SPAWB. Only CP/CPK showed more than 50% inhibition of SPAWB in the young volunteers. These findings suggest that platelet function in aged subjects is in a hyperaggregable state in vivo due to increased thromboxane A(2).

References

Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D SalveminiJ R Vane
Oct 1, 1988·European Journal of Clinical Investigation·G Gleerup, K Winther
Apr 29, 1974·Biochimica Et Biophysica Acta·M DetragliaL C Cerny
Feb 1, 1980·Journal of Pharmacological Methods·D C Cardinal, R J Flower

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Citations

Jan 1, 1997·Archives of Gerontology and Geriatrics·A SuehiroE Kakishita
Sep 18, 2004·Archives of Gerontology and Geriatrics·A SuehiroE Kakishita
Sep 29, 2012·Journal of Veterinary Emergency and Critical Care·Bo WiinbergAnnemarie T Kristensen
Jun 21, 2012·Journal of Thrombosis and Haemostasis : JTH·V G BampalisW Siess
Sep 2, 2020·Cancer Metastasis Reviews·Alessandra V S FariaGwenny M Fuhler

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