Evaluation of poly(DTH carbonate), a tyrosine-derived degradable polymer, for orthopedic applications

Journal of Biomedical Materials Research
S I ErtelJ R Parsons

Abstract

The polymerization of desaminotyrosinetyrosylhexyl ester (DTH) with phosgene gives rise to poly(DTH carbonate), a new pseudopoly(amino acid). To evaluate the performance of this bioabsorbable material in orthopedic applications, the tissue responses elicited by compression-molded pins of poly(DTH carbonate) and clinically used polydioxanone pins (PDS; Orthosorb) were compared. The two types of pins were implanted in the paravertebral muscle and in the metaphyseal proximal tibia and distal femur of 10 White New Zealand Rabbits for 1, 2, 4, and 26 weeks. The tissue response was evaluated using histologic staining of soft- and hard-tissue sections, fluorescent bone marker of incorporation, and backscattered electron imaging. In soft tissue, both poly(DTH carbonate) and PDS elicited a mild inflammatory response resulting in encapsulation. During the disintegration phase, the PDS implants triggered a foreign body response involving the phagocytosis of polymeric debris by histiocytes and giant cells. No such response was observed for poly(DTH carbonate). In hard tissue, close bone apposition was observed throughout the 26-week test period for poly(DTH carbonate) implants. At the 26-week time point, the poly(DTH carbonate) implants ex...Continue Reading

References

Jul 1, 1989·Stain Technology·D L Sterchi, J A Eurell
Jan 1, 1988·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·T Terjesen, K Apalset
Aug 1, 1994·Journal of Biomedical Materials Research·S I Ertel, J Kohn
Jan 1, 1994·Journal of Biomedical Materials Research·A S ShanbhagT T Glant
Jul 1, 1994·Journal of Applied Biomaterials : an Official Journal of the Society for Biomaterials·M S TaylorJ Heller
Apr 1, 1990·Journal of Applied Biomaterials : an Official Journal of the Society for Biomaterials·A U DanielsK P Andriano

❮ Previous
Next ❯

Citations

May 1, 1996·Journal of Biomedical Materials Research·J ChouekaJ Kohn
Jul 9, 1999·Journal of Biomedical Materials Research·R B CadyS E Chase
Sep 15, 2001·Journal of Biomaterials Science. Polymer Edition·A JohnY Tabata
Dec 18, 2002·Journal of Biomaterials Science. Polymer Edition·Anirban Sen Gupta, Stephanie T Lopina
Aug 8, 2006·Biomaterials·Yongzhong WangDavid L Kaplan
Jun 26, 2002·Annals of the New York Academy of Sciences·Linda G Griffith
Jan 1, 1996·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·K KieswetterB D Boyan
Apr 22, 2003·Nature Biotechnology·Matthias P LutolfJeffrey A Hubbell
Mar 20, 2008·The Journal of Bone and Joint Surgery. American Volume·Thomas E PattersonGeorge F Muschler
Mar 20, 2001·Journal of Biomedical Materials Research·C M Agrawal, R B Ray
Dec 26, 2001·Chemical Reviews·K E UhrichK M Shakesheff

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.