PMID: 8941972Sep 1, 1996Paper

Evaluation of polymorphonuclear cell and monocyte functions in Leishmania infantum-infected dogs

Veterinary Immunology and Immunopathology
O BrandonisioV Puccini

Abstract

Leishmania infantum is the causative agent of canine leishmaniasis in the Mediterranean area. The aspects of the canine immune response which may explain the chronic severe disease in these animals have not been well investigated. Therefore, in this work we have evaluated the parasite killing ability by circulating polymorphonuclear (PMN) cells and monocytes in dogs with spontaneous leishmaniasis and in healthy dogs. Moreover, in order to analyse the mechanisms responsible for killing activity, we evaluated the oxidative burst of circulating PMN cells, in terms of O2- and H2O2 production. The killing ability of infected dog PMN cells and monocytes was significantly lower than in a group of healthy dogs and a group of infected dogs treated with meglumine antimoniate and without symptoms of leishmaniasis. Superoxide anion and hydrogen peroxide production by PMN cells was significantly lower in a group of Leishmania-infected dogs than in healthy dogs, suggesting that these mediators may be involved in the reduced killing activity of infected dogs.

References

Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D R ParksL A Herzenberg
Mar 1, 1992·Transactions of the Royal Society of Tropical Medicine and Hygiene·M GramicciaM Troiani
Mar 1, 1992·European Journal of Epidemiology·O BrandonisioV Puccini
Jan 1, 1980·Journal of Immunological Methods·H PertoftR Seljelid
Sep 1, 1988·Parasitology Today·S J Turco
Dec 1, 1993·Parasitology Today·A Descoteaux, S J Turco

❮ Previous
Next ❯

Citations

Jul 7, 2001·Comparative Immunology, Microbiology and Infectious Diseases·M A PanaroO Brandonisio
Feb 6, 2008·The Veterinary Clinics of North America. Small Animal Practice·Peter Vajdovich
Feb 25, 2010·Veterinary Dermatology·Manolis N Saridomichelakis
Apr 11, 2015·Comparative Immunology, Microbiology and Infectious Diseases·Cláudia S MarquesGabriela M Santos-Gomes
Apr 17, 1998·Immunopharmacology and Immunotoxicology·M A PanaroO Brandonisio
Apr 21, 2016·Parasitology·Shazia HoseinLaia Solano-Gallego
Mar 19, 2013·Veterinary Parasitology·B F M AlmeidaP C Ciarlini
Dec 5, 2008·Veterinary Immunology and Immunopathology·Alexandre Barbosa ReisRodrigo Corrêa-Oliveira
Jan 4, 2015·Veterinary Immunology and Immunopathology·E I Papadogiannakis, A F Koutinas
Sep 8, 2004·Veterinary Immunology and Immunopathology·Camila Miranda de CarvalhoDominique Rigal
May 21, 2010·Veterinary Parasitology·Pablo Gómez-OchoaJuan Antonio Castillo
Aug 10, 2000·Luminescence : the Journal of Biological and Chemical Luminescence·M L VuottoD Mancino
Feb 18, 2005·The Veterinary Record·V Foglia ManzilloL Cortese
Jul 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eresso AgaTamás Laskay
Apr 20, 2019·Scientific Reports·Amanda Brito WardiniElvira Maria Saraiva

❮ Previous
Next ❯

Related Concepts