Evaluation of portal pressure by splenic perfusion measurement using dynamic CT

AJR. American Journal of Roentgenology
Y TsushimaS Kusano

Abstract

The purposes of this study were to determine if splenic perfusion measurements obtained using dynamic CT are useful in the evaluation of portal hypertension. Forty-four patients with chronic liver disease (29 men and 15 women, 49-81 years old) and 38 control subjects (17 men and 21 women, 21-79 years old) underwent dynamic CT of the spleen. Regions of interest were drawn on images of the spleen and aorta, and splenic perfusion was calculated by dividing the peak gradient of the splenic time-attenuation curve by the peak aortic CT measurement increase. In 11 patients with chronic liver disease and three patients with normal livers, we measured the wedged hepatic vein pressure (WHVP) of the right or right accessory hepatic vein to estimate portal vein pressure. Splenic perfusion was less in patients with chronic liver disease (0.894 +/- 0.324 ml/min) than in the control group (1.299 +/- 0.429 ml/min; p < .0001). We found a significant negative correlation between splenic perfusion and WHVP (r = .741; p = .0024). A significant decrease in splenic perfusion in patients with chronic liver disease negatively correlated with WHVP. Measurement of splenic perfusion may be useful in the evaluation of portal hypertension.

Citations

Jun 23, 2009·AJR. American Journal of Roentgenology·Jayant A TalwalkarRichard L Ehman
Apr 12, 2014·Digestive Diseases and Sciences·Ji Young LeeJoo Hyun Sohn
Feb 26, 2016·European Radiology·Michael A FischerTorkel B Brismar
Apr 12, 2018·Journal of Magnetic Resonance Imaging : JMRI·Mathilde WagnerBachir Taouli
Sep 15, 2020·Abdominal Radiology·Paul KennedyBachir Taouli
Mar 6, 2004·Nihon Hoshasen Gijutsu Gakkai zasshi·Shintaro FunabasamaKatsumi Inoue
Jun 8, 2018·Clinical Endoscopy·Jason B Samarasena, Kenneth J Chang

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