Evaluation of Postoperative Serum MACC1 in the Prognosis of Laparoscopic Complete Mesocolic Excision for Colon Cancer.

Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
Ming ZhangWeiping Wang

Abstract

To investigate the correlation between postoperative serum metastasis-associated in colon cancer-1 (MACC1) and prognosis of colon cancer patients after laparoscopic complete mesocolic excision (CME). A total of 280 colon cancer patients undergoing laparoscopic CME were included. The 40-month disease-free survival, progression-free survival, and overall survival were calculated. Immunohistochemical staining, western blotting, and quantitative real-time polymerase chain reaction results showed that the MACC1 expression in cancer tissues was significantly higher than adjacent tissues (P<0.05). Compared with the small interfering RNA-negative control group, the tumor weight, tumor volume, and tumor number were all significantly decreased after treatment with small interfering RNA-MACC1 (P<0.05). Survival analysis showed that compared with the low MACC1 group, the disease-free survival (χ2=30.095, P<0.001), progression-free survival (χ2=50.027, P<0.001), and overall survival (χ2=53.861, P<0.001) in the high MACC1 group all decreased significantly. Postoperative serum MACC1 has a potential value for evaluating the prognosis of patients undergoing laparoscopic CME.

References

Feb 27, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Dong JiYing-Min Yao
Dec 18, 2019·Journal of Experimental & Clinical Cancer Research : CR·Ruitao ZhangMinghui Zhang
Dec 25, 2019·International Journal of Colorectal Disease·Sung Chul LeeJung Kyong Shin
Jan 26, 2020·International Journal of Colorectal Disease·Ioannis BaloyiannisGeorge Tzovaras
Jan 31, 2020·World Journal of Surgical Oncology·Chi Chung FooWai Lun Law
Feb 3, 2020·Lancet·Adrian V Specogna, Frank A Sinicrope

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Methods Mentioned

BETA
dissection
Enzyme-linked immunosorbent assay
transfection
electrophoresis
Polymerase Chain Reaction

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