Evaluation of potential gender-related differences in behavioral and cognitive alterations following pilocarpine-induced status epilepticus in C57BL/6 mice

Physiology & Behavior
Clarissa Vasconcelos de OliveiraMauro Schneider Oliveira

Abstract

Together with pharmacoresistant seizures, the quality of life of temporal lobe epilepsy (TLE) patients is negatively impacted by behavioral comorbidities including but not limited to depression, anxiety and cognitive deficits. The pilocarpine model of TLE has been widely used to study characteristics of human TLE, including behavioral comorbidities. Since the outcomes of pilocarpine-induced TLE might vary depending on several experimental factors, we sought to investigate potential gender-related differences regarding selected behavioral alterations in C57BL6 mice. We found that epileptic mice, independent of gender, displayed increased anxiety-like behavior in the open-field test. In the object recognition test, epileptic mice, regardless of gender, showed a decreased recognition index at 24 (but not at 4) hours after training. On the other hand, no significant differences were found regarding mice learning and memory performance in the Barnes maze paradigm. Motor coordination and balance as assessed by the beam walk and rotarod tests were not impaired in epileptic mice of both genders. However, female mice, independent of epilepsy, performed the beam walk and rotarod tasks better than their male counterparts. We also found th...Continue Reading

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Citations

Oct 14, 2016·Epilepsy & Behavior : E&B·Isabel Vieira de Assis LimaAntonio Carlos Pinheiro de Oliveira
Feb 7, 2019·Behavioural Pharmacology·Solange BandieraRosane Gomez
Mar 30, 2017·Cognitive Neurodynamics·Hui TangJiaquan He
Feb 18, 2019·Neuropsychopharmacology Reports·Hideo HagiharaTsuyoshi Miyakawa
Apr 5, 2018·Journal of Alzheimer's Disease : JAD·Woojin Scott KimJohn B J Kwok
May 1, 2021·International Journal of Molecular Sciences·Claudia Espinosa-GarciaAsheebo Rojas

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