Evaluation of potential mechanisms of atrazine-induced reproductive impairment in fathead minnow (Pimephales promelas) and Japanese medaka (Oryzias latipes)

Environmental Toxicology and Chemistry
Catherine A RichterDonald E Tillitt

Abstract

Atrazine has been implicated in reproductive dysfunction of exposed organisms, and previous studies documented decreased egg production in Japanese medaka (Oryzias latipes) and fathead minnows (Pimephales promelas) during 30-d to 38-d exposures to 0.5 µg/L, 5 µg/L, and 50 µg/L atrazine. The authors evaluated possible mechanisms underlying the reduction in egg production. Gene expression in steroidogenesis pathways and the hypothalamus-pituitary-gonad axis of male and female fish was measured. Atrazine did not significantly induce gonad aromatase (cyp19a1a) expression. An atrazine-induced shift in the number of females in an active reproductive state was observed. Expression of the egg maturation genes vitellogenin 1 (vtg1) and zona pellucida glycoprotein 3.1 (zp3.1) in medaka females was correlated and had a bimodal distribution. In both species, females with low vtg1 or zp3.1 expression also had low expression of steroidogenesis genes in the gonad, estrogen receptor in the liver, and gonadotropins in the brain. In the medaka, the number of females per tank that had high expression of zp3.1 was significantly correlated with egg production per tank. The number of medaka females with low expression of zp3.1 increased significantl...Continue Reading

References

Sep 11, 1998·Archives of Environmental Contamination and Toxicology·P Saglio, S Trijasse
Jun 12, 2001·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·A Moore, N Lower
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jun 13, 2002·Environmental Health Perspectives·Edward F OrlandoLouis J Guillette
Feb 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yong ZhuPeter Thomas
Jan 10, 2004·Environmental Toxicology and Chemistry·Adriana C Bejarano, G Thomas Chandler
Apr 21, 2004·Environmental Toxicology and Chemistry·Robert B BringolfRobert C Summerfelt
Jan 24, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mark T RobergeGerald Larsen
Apr 20, 2007·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Ralph L CooperTammy E Stoker
Jun 23, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Kristina PogrmicRadmila Kovacevic
Aug 28, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Melanie J P FraitesSusan C Laws
Jan 9, 2010·Environmental Health Perspectives·Jason R Rohr, Krista A McCoy
May 18, 2010·Aquatic Toxicology·Donald E TillittCatherine A Richter
Mar 23, 2011·The Journal of Steroid Biochemistry and Molecular Biology·Tyrone B HayesEmily Willingham
Apr 2, 2014·Environmental Toxicology and Chemistry·Frederieke J KroonHannah L Osborn
Jun 16, 2014·Aquatic Toxicology·Diana M PapouliasCatherine A Richter
Sep 18, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Agnes L Karmaus, Timothy R Zacharewski

❮ Previous
Next ❯

Citations

Feb 16, 2017·Environmental Toxicology and Chemistry·Alan J HosmerRichard A Brain
Aug 30, 2020·Ecotoxicology and Environmental Safety·Jiechen YinYuanqing Bu
May 21, 2019·Environmental Pollution·Jacob A ClearyRamji K Bhandari
Jun 16, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Changwon YangGwonhwa Song

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.