Evaluation of potential pro-survival pathways regulated by melatonin in a murine senescence model

Journal of Pineal Research
Javier Gutierrez-CuestaMerce Pallas

Abstract

We examined the effect of melatonin on pro-survival processes in three groups of mice. Untreated senescence-accelerated mice (SAMP8), melatonin-treated SAMP8 and untreated senescence-accelerated resistant mice (SAMR1) of 10 months old were studied. Melatonin (10 mg/kg) or vehicle (ethanol at 0.066%) was supplied in the drinking water from the end of the first month until the end of the ninth month of life. Differences in the Akt/Erk1-2 pathway and downstream targets were examined and no significant changes were observed, except for beta-catenin. However, sirtuin 1 expression was significantly lower in SAMP8 than in SAMR1. In addition, acetylated p53 and NFkappaB expression were lower in SAMP8 than in SAMR1. These changes were prevented by melatonin. Moreover, the concentration/expression of alpha-secretase was lower and that of amyloid beta aggregates (Abeta) was higher in untreated SAMP8 than in SAMR1. Likewise, the levels of Bid were higher, whereas Bcl-2(XL) levels were lower in SAMP8 than in SAMR1. Melatonin reduced all these changes. We conclude that melatonin improves pro-survival signals and reduces pro-death signals in age-related impairments of neural processes.

References

Aug 2, 1996·The Journal of Biological Chemistry·D J Selkoe
Mar 29, 2001·Journal of Pineal Research·D Acuña-CastroviejoR J Reiter
Sep 5, 2002·Nature Reviews. Cancer·Suzanne Cory, Jerry M Adams
Sep 11, 2002·Trends in Cell Biology·Jeffrey Smith
Oct 26, 2002·Science·Andrew DillinCynthia Kenyon
Sep 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hongbo R LuoSolomon H Snyder
Oct 3, 2003·Ageing Research Reviews·Ralph A Nixon
Nov 5, 2003·Journal of Neuroscience Research·Tobias M J AllinsonNigel M Hooper
Jan 27, 2004·Journal of Leukocyte Biology·Stephen W BuckJeffrey S Smith
May 6, 2004·The Journal of Biological Chemistry·Armando van der HorstBoudewijn M T Burgering
Jun 11, 2004·Annual Review of Biochemistry·Gil Blander, Leonard Guarente
Sep 1, 1994·Archives of Gerontology and Geriatrics·T TakedaH Katoh
Nov 5, 2004·The Journal of Pharmacology and Experimental Therapeutics·Leo H WangEugene M Johnson
Nov 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Pascale N LacorWilliam L Klein
Dec 25, 2004·Journal of Pineal Research·Josefa LeónRussel J Reiter
Feb 5, 2005·Trends in Biochemical Sciences·Lars P van der Heide, Marten P Smidt
Feb 5, 2005·The EMBO Journal·Yonghua YangWenlong Bai
Mar 24, 2005·Journal of Cellular and Molecular Medicine·Gang SongShideng Bao
Sep 15, 2005·The FEBS Journal·Olivera GrubishaJohn M Denu
Sep 21, 2005·Mechanisms of Ageing and Development·Anna M CanudasMercè Pallàs
Sep 27, 2005·The Journal of Biological Chemistry·Jennifer ChenLi Gan
Mar 7, 2006·Biogerontology·Oscar Alvarez-GarcíaAna Coto-Montes
Dec 14, 2006·Free Radical Research·María I RodríguezDarío Acuña-Castroviejo
Dec 22, 2006·Journal of Alzheimer's Disease : JAD·Weiping QinGiulio Maria Pasinetti
Jan 3, 2007·Journal of Pineal Research·M D MaldonadoR J Reiter
Mar 14, 2007·Journal of Pineal Research·José L MaurizJavier González-Gallego
Mar 14, 2007·Journal of Pineal Research·Karuppagounder S SaravananKochupurackal P Mohanakumar
Mar 14, 2007·Journal of Pineal Research·María I RodríguezDarío Acuña-Castroviejo
Apr 19, 2007·Journal of Pineal Research·Javier Gutierrez-CuestaMercè Pallàs
Apr 24, 2007·The Biochemical Journal·Shaday Michan, David Sinclair
Jan 29, 2008·Recent Patents on CNS Drug Discovery·Mercè PallàsAntoni Camins

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Citations

Apr 6, 2013·Biogerontology·D Pérez-CáceresM Pallàs
Nov 24, 2011·Age·Luigi Fabrizio RodellaRita Rezzani
May 15, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Brittney Jung-Hynes, Nihal Ahmad
Nov 20, 2013·Inflammatory Bowel Diseases·Gopabandhu Jena, Priyanka P Trivedi
Jun 13, 2014·Cellular and Molecular Life Sciences : CMLS·Jerry Vriend, Russel J Reiter
Sep 24, 2014·International Journal of Molecular Sciences·Anorut JenwitheesukPiyarat Govitrapong
Oct 14, 2014·International Journal of Molecular Sciences·Rüdiger Hardeland
Apr 4, 2012·Expert Opinion on Drug Discovery·Ester VerdaguerAntoni Camins
Sep 16, 2014·Life Sciences·Jerry Vriend, Russel J Reiter
Mar 7, 2012·Hormones and Behavior·Daniel P CardinaliPablo Scacchi
Apr 27, 2010·Toxicology·Dominique Bonnefont-Rousselot, Fabrice Collin
Jul 4, 2009·Journal of Pineal Research·Miguel CarreteroDarío Acuña-Castroviejo
Sep 9, 2009·Annals of the New York Academy of Sciences·William C Bushell, Neil D Theise
Jul 15, 2011·Journal of Pineal Research·Virginia MotilvaMatilde Illanes
Dec 23, 2009·Journal of Pineal Research·Brittney Jung-HynesNihal Ahmad
Oct 13, 2009·CNS Neuroscience & Therapeutics·Xin Wang
May 19, 2012·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Yin ShiYing-Ying Zhang
Dec 22, 2014·Molecular and Cellular Endocrinology·Jerry Vriend, Russel J Reiter
Dec 3, 2014·Neurobiology of Aging·Sergi BayodAnna-Maria Canudas
Jul 3, 2015·Life Sciences·Hardeep Singh TuliSardul Singh Sandhu
Aug 30, 2013·Journal of Pharmacological Sciences·Golmaryam SarlakPiyarat Govitrapong
Apr 1, 2015·Mechanisms of Ageing and Development·Margarita R RamisRussel J Reiter
Jul 17, 2014·Journal of Molecular Neuroscience : MN·Sergi BayodMercè Pallàs
Oct 21, 2016·Journal of Pineal Research·Rüdiger Hardeland
Jan 22, 2017·Journal of Pineal Research·Juan C MayoRussel J Reiter
Jun 29, 2017·Journal of Pineal Research·Almudena CrookeJesús Pintor
Aug 3, 2017·Molecular Brain·Juhyun SongByeong C Kim
Mar 3, 2018·Journal of Neuroscience Research·B S Alghamdi
Jun 17, 2018·Journal of Pineal Research·Rubén CorpasBárbara R Cardoso

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