Evaluation of povidone-iodine as a disinfectant solution for contact lenses: antimicrobial activity and cytotoxicity for corneal epithelial cells

Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association
Ryoji YanaiTeruo Nishida

Abstract

Povidone-iodine (PVP-I) possesses broad-spectrum antimicrobial activity and is used clinically as a disinfectant. We evaluated the disinfectant properties and safety of PVP-I for use as a contact lens solution. The concentrations of PVP-I required to reduce the number of Staphylococcus aureus or Candida albicans by 3 log units were lower than were those of hydrogen peroxide, polyhexamethylene biguanide (PHMB), and benzalkonium chloride (BAK). The cytotoxicity of PVP-I for cultured human corneal epithelial (HCE) cells was less than that of the other three agents. The safety margin for PVP-I was thus greatest among the tested compounds. PVP-I appears suited for use as a contact lens disinfectant.

References

Jun 1, 1975·Archives of Ophthalmology·A R GassetD Katzin
Nov 1, 1992·Archives of Ophthalmology·T D MatthewsJ K Dart
Jan 1, 1992·The CLAO Journal : Official Publication of the Contact Lens Association of Ophthalmologists, Inc·R LoweN A Brennan
Sep 21, 1989·The New England Journal of Medicine·E C PoggioK R Kenyon
Jul 1, 1988·American Journal of Optometry and Physiological Optics·M G HarrisL Tracewell
Mar 2, 1995·The New England Journal of Medicine·A Foster, V Klauss
Feb 1, 1996·Optometry and Vision Science : Official Publication of the American Academy of Optometry·P S SoniJ Ross
Jan 5, 2002·Ophthalmology·Thomas A CiullaSamuel Masket
Jun 19, 2003·The British Journal of Ophthalmology·T BourcierL Laroche
Oct 15, 2003·Clinical Microbiology Reviews·Philip A Thomas
Jul 1, 2004·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Kiyonori FurukawaTakashi Tajiri
Dec 18, 2004·Cornea·Jeane Haidee Mah-SadorraElisabeth J Cohen
Feb 11, 2005·Contact Dermatitis·Jean-Marie Lachapelle
Mar 19, 2005·The British Journal of Ophthalmology·P B MorganA B Tullo
Aug 9, 2005·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Nathan EfronAndrew B Tullo
Nov 24, 2005·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·D V SealUNKNOWN Keratitis Study Group
Nov 24, 2005·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Ruth A RosenthalBarry A Schlech

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Citations

Sep 5, 2008·Drug Development and Industrial Pharmacy·Ibrahim A AlsarraFars K Alanazi
Sep 2, 2014·Journal of Cataract and Refractive Surgery·Goichiro MiyakeMasayoshi Iwaki
Jun 14, 2017·Optometry and Vision Science : Official Publication of the American Academy of Optometry·William H RidderJames Burke
Jan 18, 2017·The Korean Journal of Parasitology·Eun-Kyung MoonHyun-Hee Kong
Oct 7, 2017·Current Opinion in Ophthalmology·Andrzej GrzybowskiWilliam G Myers
Apr 22, 2015·Antimicrobial Agents and Chemotherapy·Eun-Kyung MoonHyun-Hee Kong
Jun 10, 2020·European Journal of Ophthalmology·Khayam NaderiDavid O'Brart
Oct 5, 2018·Nanoscale Research Letters·Guo-Sai LiuYun-Ze Long
Nov 5, 2020·European Journal of Ophthalmology·Siddharth Madan, Sarita Beri
Feb 7, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Sin Wan CheungPauline Cho
May 28, 2021·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Masahiro NakagawaAjay Kumar Vijay

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