Evaluation of prediagnostic prostate-specific antigen dynamics as predictors of death from prostate cancer in patients treated conservatively.

International Journal of Cancer. Journal International Du Cancer
Matthew F O'BrienTrans-Atlantic Prostate Group

Abstract

Prostate-specific antigen (PSA) dynamics have been proposed to predict outcome in men with prostate cancer. We assessed the value of PSA velocity (PSAV) and PSA doubling time (PSADT) for predicting prostate cancer-specific mortality (PCSM) in men with clinically localized prostate cancer undergoing conservative management or early hormonal therapy. From 1990 to 1996, 2,333 patients were identified, of whom 594 had two or more PSA values before diagnosis. We examined 12 definitions for PSADT and 10 for PSAV. Because each definition required PSA measurements at particular intervals, the number of patients eligible for each definition varied from 40 to 594 and number of events from 10 to 119. Four PSAV definitions, but no PSADT, were significantly associated with PCSM after adjustment for PSA in multivariable Cox proportional hazards regression. All four could be calculated only for a proportion of events, and the enhancements in predictive accuracy associated with PSAV had very wide confidence intervals. There was no clear benefit of PSAV in men with low PSA and Gleason grade 6 or less. Although evidence that certain PSAV definitions help to predict PCSM in the cohort exist, the value of incorporating PSAV in predictive models to...Continue Reading

References

May 1, 1995·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·N Coyle
Feb 1, 1996·International Journal of Radiation Oncology, Biology, Physics·G E HanksT E Schultheiss
May 11, 1999·JAMA : the Journal of the American Medical Association·C R PoundP C Walsh
Jul 27, 2001·Journal of Clinical Epidemiology·E W SteyerbergJ D Habbema
Sep 18, 2003·Journal of the National Cancer Institute·Anthony V D'AmicoMing-Hui Chen
Jul 13, 2004·The New England Journal of Medicine·Anthony V D'AmicoWilliam J Catalona
Apr 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew R SmithCelestia S Higano
Jul 28, 2005·JAMA : the Journal of the American Medical Association·Stephen J FreedlandAlan W Partin
Jul 28, 2005·JAMA : the Journal of the American Medical Association·Anthony V D'AmicoMing-Hui Chen
Jan 31, 2006·European Urology·Fritz H SchröderChris H Bangma
Apr 20, 2006·Journal of the National Cancer Institute·Ian M ThompsonCharles A Coltman
May 18, 2006·Journal of the National Cancer Institute·Andrew J StephensonMichael W Kattan
Oct 31, 2006·The Journal of Urology·Timothy J DaskivichWilliam K Oh
Nov 2, 2006·Journal of the National Cancer Institute·H Ballentine CarterE Jeffrey Metter
Nov 2, 2006·British Journal of Cancer·J CuzickUNKNOWN Transatlantic Prostate Group
Apr 5, 2007·Journal of the National Cancer Institute·Katja FallUNKNOWN Scandinavian Prostate Cancer Group Study No. 4
Oct 11, 2007·Journal of the National Cancer Institute·Ruth D EtzioniIan M Thompson
Dec 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew J VickersHans Lilja
Mar 20, 2009·The New England Journal of Medicine·Fritz H SchröderUNKNOWN ERSPC Investigators

❮ Previous
Next ❯

Citations

Jun 20, 2012·British Journal of Medical & Surgical Urology·Andrew J Vickers, Simon F Brewster
Dec 19, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F B ThomsenUNKNOWN Scandinavian Prostate Cancer Group
Nov 6, 2012·European Urology·Laurence Klotz
Jun 7, 2011·International Journal of Radiation Oncology, Biology, Physics·Jessica J ParkAnthony V D'Amico

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.