Evaluation of Prediction of Polymorphisms of DNA Repair Genes on the Efficacy of Platinum-Based Chemotherapy in Patients With Non-Small Cell Lung Cancer: A Network Meta-Analysis

Journal of Cellular Biochemistry
Shao-Nan YuShu-Hua Zhang

Abstract

This network meta-analysis (NMA) was conducted to compare the predictive value of 14 SNPs in eight DNA repair genes on the efficacy of platinum-based chemotherapy in patients with non-small cell lung cancer (NSCLC). These included ERCC1 (rs11615, rs3212986, rs3212948), XRCC1 (rs25487, rs25489, rs1799782), XPD (rs13181, rs1799793), XPG (rs1047768, rs17655), XPA (rs1800975), XRCC3 (rs861539), APE1 (rs3136820), and RRM1 (rs1042858). The PubMed and Cochrane library databases were reviewed from their inception to February 2017 and studies which met our inclusion criteria were included in our investigation. This network meta-analysis combines direct and indirect evidence to assess the predictive value of 14 SNPs in eight DNA repair genes on the efficacy of platinum-based chemotherapy in NSCLC. We evaluated the predictive value through the use of the odd ratios (OR) and drawing surface under the cumulative ranking curves (SUCRA). A total of 26 eligible cohort studies were enrolled in this NMA. The pairwise meta-analysis indicated that in terms of overall response ratio (ORR), ERCC1 (rs11615), XRCC1 (rs25487, rs1799782), and XPD (rs13181) polymorphisms are associated with the efficacy of platinum-based chemotherapy in NSCLC. The result...Continue Reading

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Citations

Dec 12, 2017·Expert Opinion on Drug Metabolism & Toxicology·Gerhard Hamilton, Barbara Rath
Jan 9, 2020·Scientific Reports·Dilara AyyildizSilvano Piazza
Oct 30, 2020·Pharmacogenomics and Personalized Medicine·Nadiya Nurul AfifahMelisa I Barliana
Mar 8, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chen-Xue MaoZhao-Qian Liu

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