Evaluation of Premature Membrane Exposure and Early Healing in Guided Bone Regeneration of Peri-Implant Dehiscence and Fenestration Defects With a Slowly Resorbing Porcine Collagen Ribose Cross-Linked Membrane: A Consecutive Case Series

Clinical Advances in Periodontics
E Todd Scheyer, Michael K McGuire

Abstract

Guided bone regeneration (GBR) is a well-known and accepted procedure for effective treatment of oral bony defects that is dependent on sustained barrier membrane function for adequate new bone formation. Cross-linking between collagen fibrils with various agents has proven to be effective in prolonging membrane integrity and function, both critical to positive bone regenerative outcomes. Overlying mucosal dehiscence with membrane exposure may lead to less than adequate new bone formation. The current case series examines guided bone regenerative outcomes for peri-implant defects using a ribose cross-linked porcine collagen membrane that appears to reduce the risk of cross-linking-associated membrane exposure. Seven patients with nine sites having peri-implant dehiscence and fenestration defects were enrolled in this consecutive case series pilot study. At surgery, the linear range of implant thread exposure was 5 to 10 mm (mean of ≈6.3 mm). After implant insertion, grafting with mineralized allograft, and placement of a ribose cross-linked collagen membrane, patients were followed for a minimum of 6 months. At 6-month reentry surgery, all dehiscence and fenestration defects were eliminated with newly regenerated bone covering ...Continue Reading

References

Jan 15, 1995·The Biochemical Journal·A J BaileyE P Halligan
Feb 4, 2003·Clinical Oral Implants Research·Tae-Ju OhHom-Lay Wang
May 10, 2005·Clinical Oral Implants Research·Daniel RothamelJürgen Becker
Dec 11, 2007·Journal of Biomedical Materials Research. Part a·Anton FriedmannJean-Pierre Bernimoulin
May 6, 2008·Journal of Periodontology·Ofer MosesCarlos E Nemcovsky
Jun 7, 2008·Journal of Periodontology·Yuval ZuberyArie Goldlust
Nov 13, 2010·Journal of Periodontal & Implant Science·Chang-Kyun LeeJue-Yeon Lee

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Citations

Apr 26, 2019·Stem Cells and Development·Ana-Maria SeciuOtilia Zarnescu

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