Evaluation of pretransplant serum cytokine levels in renal transplant recipients

Transplantation Proceedings
I BerberI Titiz

Abstract

Cytokines are early predictors of graft dysfunction. In this study we evaluated pretransplant cytokine levels and graft outcomes among renal transplant recipients. Donor selection was based on results of blood group matching and negative crossmatches. A panel of 35 human serum samples from patients (female/male = 0.4) awaiting renal transplantation and 15 healty control sera were analyzed for interleukin (IL) 1alpha, IL-2, IL-6, IL-10, tumor necrosis factor-alpha, interferon-gamma, transforming growth factor-beta concentrations by enzyme-linked immunosorbent assay. The average age of the patients was 34.5 +/- 10.1 years (range 15 to 60). The average duration of renal replacement therapy before renal transplantation was 42.1 +/- 57.9 months (range 0 to 288). The types of renal replacement therapy were; hemodialysis (n = 27) and CAPD (n = 8). Pretransplant IL-6 levels were higher among recipients who displayed acute rejection episodes compared with those fact of this complications (P < .05) or control sera (P < .05). Pretransplant IL-6 levels were higher among recipients with graft failure than those with a functioning graft (P < .05). Pretransplant IL-10 levels were higher among recipients with acute rejection episodes and graft...Continue Reading

References

Jan 13, 2010·Clinical Microbiology Reviews·Nicasio ManciniMassimo Clementi
Dec 17, 2009·Transplantation Proceedings·M KarczewskiM Glyda
Oct 29, 2008·Clinics in Chest Medicine·Corey E Ventetuolo, Mitchell M Levy
Apr 1, 2010·Pediatric Transplantation·Silke V NiederhausStuart J Knechtle
Jul 7, 2016·Mediators of Inflammation·Dorota KamińskaMarian Klinger
Dec 23, 2016·Expert Review of Molecular Diagnostics·Li Zhang, C M Rickard

Related Concepts

Hemodialysis
Interleukins
Transforming Growth Factor beta
Tumor Necrosis Factor-alpha
Pancreatitis, Graft
Recombinant Interleukin-10
Anti-Inflammatory Agents
Kidney
Phosphoglycerate Dehydrogenase Activity
Mating Type Switching Donor Selection

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