PMID: 6406882May 1, 1983Paper

Evaluation of propylene oxide for mutagenic activity in 3 in vivo test systems

Mutation Research
B D HardinR J Smith

Abstract

Propylene oxide (CAS No. 75-56-9) was tested for mutagenic activity following vapor exposure using 3 in vivo test systems. Rat dominant lethal and mouse sperm-head morphology assays were conducted using males exposed to propylene oxide at 300 ppm in a dynamic exposure chamber for 7 h per day on 5 consecutive days. A sex-linked recessive lethal test in Drosophila melanogaster employed a 24-h static exposure to propylene oxide at 645 ppm. Male mice were killed 1, 3, 5, 7, and 9 weeks post-exposure for evaluation of sperm-head morphology. Propylene oxide exposure did not result in an increase in abnormal forms. Male rats were mated with 2 virgin females per week for 6 weeks following exposure. A statistically significant increase in preimplantation losses and a statistically significant reduction in the number of living implants in the first post-exposure week did not appear to be treatment related. A highly significant increase in sex-linked recessive lethal mutations was observed in two germ cell stages (mature sperm and developing spermatocytes). These results warrant continued caution in potential human exposure to propylene oxide.

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Citations

Feb 1, 1988·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C F KuperH Verschuuren
Dec 31, 1997·Mutation Research·M N Ríos-BlancoJ A Swenberg
Oct 12, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Melva N Ríos-BlancoJames A Swenberg
Dec 21, 2006·Journal of Occupational Health·Hirokazu OkudaTaijiro Matsushima
Oct 1, 1984·Toxicology and Applied Pharmacology·D W LynchB Y Cockrell
Jan 1, 1988·Annals of the New York Academy of Sciences·A CilibertiG Perino
Oct 26, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·György A Csanády, Johannes G Filser
Sep 1, 1986·Toxicology and Industrial Health·W MeylanJ F Stara
Jan 1, 1986·Teratogenesis, Carcinogenesis, and Mutagenesis·J D TuckerT M Ong
Jul 31, 2007·Critical Reviews in Toxicology·Richard J Albertini, Lisa M Sweeney
Jan 1, 1994·Environmental and Molecular Mutagenesis·E T SnowJ J Solomon
May 14, 2004·Environmental and Molecular Mutagenesis·Dale M WalkerVernon E Walker
Dec 1, 1991·Regulatory Toxicology and Pharmacology : RTP·R NilssonE V Sargent

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