Evaluation of protective effect of bee pollen against propoxur toxicity in rat

Ecotoxicology and Environmental Safety
Gokhan EraslanZeynep Soyer Sarica

Abstract

In this study, 28 Wistar female rats (200-250g) were used and divided into four equal groups. Group 1 was allocated as the control group. Groups 2-4 were administered 100mg/kg/bw/day bee pollen, 20mg/kg/bw/day propoxur, and 100mg/kg/bw/day bee pollen plus 20mg/kg/bw/day propoxur by gavage for 14 days, respectively. At the end of the 14th day, blood and tissues (the liver, kidney, brain, and heart) were collected from all animals. Oxidative stress markers (MDA, CAT, SOD, GSH-Px) and some other biochemical parameters (total protein, albumin, glucose, cholesterol, triglyceride, BUN, creatinine, uric acid, magnesium, sodium, potassium, chloride, total bilirubin, GGT, LDH, AST, ALT, and ALP) were analyzed. According to the data obtained, propoxur was determined to lead to negative changes in most of the biochemical parameters investigated and the administration of bee pollen was determined to alleviate these effects.

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Citations

Dec 17, 2009·Naunyn-Schmiedeberg's Archives of Pharmacology·Kapil Dev MehtaKrishna K Sharma
May 13, 2014·BioMed Research International·María Guadalupe Prado-OchoaFernando Alba-Hurtado
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Mar 23, 2010·Ecotoxicology and Environmental Safety·Gökhan EraslanMürsel Karabacak
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Nov 2, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yawei ZhangZengqi Peng
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