Evaluation of protective effects of diosmin (a citrus flavonoid) in chemical-induced urolithiasis in experimental rats

Pharmaceutical Biology
V Vinoth PrabhuSudhakar Pachiappan

Abstract

Context There have not been any conclusive studies of the effects of diosmin, a modified flavanone glycoside obtained from Teucrium gnaphalodes L'Her (Lamiaceae), on urolithiasis. Objective To evaluate anti-urolithiatic effects of diosmin in ammonium chloride and ethylene glycol-induced renal stone in experimental animals. Materials and methods Thirty Sprague-Dawley were divided into five groups (n=6) receiving the following treatments, respectively, p.o. for 15 consecutive days: distilled water, 0.75% v/v ethylene glycol + 2% w/v ammonium chloride, 0.75% v/v ethylene glycol + 2% w/v ammonium chloride + cystone® 750 mg/kg, 0.75% v/v ethylene glycol + 2% w/v ammonium chloride + diosmin 10 mg/kg or 0.75% v/v ethylene glycol + 2% w/v ammonium chloride + diosmin 20 mg/kg. Different biomarkers of urolithiasis in urine and serum were evaluated and histopathological examination of kidney was done. Results Animals treated with diosmin (both 10 and 20 mg/kg) had significantly (p < 0.005) decreased in kidney weight, urinary pH, total urinary protein, urinary calcium, phosphorus, serum potassium, sodium, magnesium, creatinine, uric acid and blood urea nitrogen levels and significantly (p < 0.005) increased in urinary volume, urinary magne...Continue Reading

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Citations

Jun 20, 2017·Chemico-biological Interactions·Mariana M BertozziWaldiceu A Verri
Mar 10, 2018·International Journal of Molecular Sciences·Mina Cheraghi NirumandAnupam Bishayee
Feb 13, 2018·Critical Reviews in Food Science and Nutrition·Xiangquan ZengWeibo Jiang
Apr 15, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Peng YuanZhiqiang Chen
Sep 30, 2020·Current Drug Targets·Esteban EmilianiAndres Koey Kanashiro

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