Abstract
Many of the hypotheses have been suggested to explain the mechanism of the secondary effects of traumatic spinal cord injury (TSCI) as follows: ischaemia/reperfusion disability theory, free radicals theory, exitotoxicity theory, immunological destruction theory, apoptosis theory. Recently, free radicals,lipid peroxidation reactions and apoptosis theories have been much more accepted than others. In this study, possible protective effects of the alpha lipoic acid were evaluated in the traumatic spinal cord of rats. Using a well characterised weight drop technique, spinal cord contusions were formed to 48 Wistar albino rats at thoracal 8–10 level. After alpha lipoic acid and methylprednisolone were administered intraperitoneally, the spinal cord tissues were harvested for histopathological and biochemical studies. Histopathological examination results showed that neither methylprednisolone nor alpha lipoic acid can play an act to decrease or block the neural tissue destruction and necrosis in hyperacute and subacute stage of the TSCI in rats. Biochemical study results showed that alpha lipoic acid was much more decreased the lipid peroxidation levels than methylprednisolone in subacute stage. However, none of the agents was chang...Continue Reading
References
Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Dec 5, 1991·The New England Journal of Medicine·T F BaderM O Favorov
Jun 27, 1991·The New England Journal of Medicine·F H GeislerW P Coleman
Nov 1, 1985·Journal of Pharmacological Methods·K M MullaneB Smith
Nov 1, 1986·Neurosurgery·P BlackK C Wachs
Jan 1, 1995·Neurosurgical Review·F IldanA Karadayi
Aug 15, 1996·Journal of Neuroscience Research·P G PopovichC C Whitacre
Jan 1, 1997·Free Radical Biology & Medicine·L PackerK Wessel
Sep 1, 1997·General Pharmacology·G P BiewengaA Bast
Aug 12, 1998·BioFactors·S Roy, L Packer
Oct 31, 1998·Neurosurgical Review·M Y KaynarN Ciplak
Mar 7, 2002·Journal of Orthopaedic Trauma·A MerolaN J Espat
Jul 27, 1951·Science·L J REEDC S HORNBERGER
Jun 15, 2004·Brain Research·Gabriel Guízar-SahagúnIgnacio Madrazo
Nov 30, 2004·Trends in Molecular Medicine·Michael S Beattie
Jul 20, 2005·Treatments in Endocrinology·Dan Ziegler
Mar 6, 2008·Clinical and Experimental Pharmacology & Physiology·Vipin Dhote, Ramachandran Balaraman
Jul 1, 2009·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Sergio TorresGabriel Guizar-Sahagún
Citations
May 9, 2012·Ecotoxicology and Environmental Safety·Azza I OthmanAml A El-Sayed
Jan 15, 2015·TheScientificWorldJournal·Mehar Naseem, Suhel Parvez
Dec 1, 2017·Nutritional Neuroscience·Fatemeh SeifarSeied Kazem Shakouri