Evaluation of psychoemotional status of rats after brain injury and systemic transplantation of mesenchymal stem cells

Bulletin of Experimental Biology and Medicine
A F TsybE P Ananyeva

Abstract

We studied the effects of systemic transplantation of mesenchymal stem cells obtained after culturing of autologous bone marrow on psychophysiological status of Wistar rats after diffuse brain trauma. Two months after systemic injection of mesenchymal stem cells we observed a decrease in manifestations of emotional behavioral reactions (anxiety and excitability) and shortening of the time of realization of drinking behavior in a T-maze. A significant positive effect of systemic transfusion of mesenchymal stem cells on avoidance conditioning in a shuttle box was observed 3 months after brain injury.

References

Apr 2, 1999·Science·M F PittengerD R Marshak
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Dec 31, 2003·Experimental Neurology·S SongJ Sanchez-Ramos
Nov 24, 2004·Differentiation; Research in Biological Diversity·Tatiana TondreauDominique Bron
May 5, 2005·Experimental Neurology·P Lu, M H Tuszynski
May 2, 2006·Stem Cells and Development·Netta R BlondheimDaniel Offen

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Citations

Sep 15, 2012·Bulletin of Experimental Biology and Medicine·R A PoltavtsevaG T Sukhikh

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