Evaluation of PUVA, topical corticosteroids and the combination of both in the treatment of psoriasis

The British Journal of Dermatology
M SchmollE Christophers

Abstract

A total of 90 patients with psoriasis were treated either by photochemotherapy (PUVA) or by topical steroids under occlusion (TOC). In a third group of patients a combination of both regimens was applied. All patients received approximately 15 treatments of either type. During therapy, biopsies were taken in all treatment groups and the epidermal thickness was monitored planimetrically. After clearing of the skin the patients were left without treatment and the time of onset of new lesions was recorded. While TOC produced rapid clearing of the skin this was followed by early relapses (in 50% of the patients after 3 weeks). PUVA reduced psoriatic hyperplasia more slowly; however, 50% of the patients remained free of psoriasis for approximately 10 weeks after clearance. Psoriasis treated with steroids under occlusion together with PUVA showed a significantly faster return of the skin to normal as compared to PUVA. As in PUVA-treated patients relapses occurred after approximately 12 weeks is this group. Therefore the combination of both treatments appears to be advantageous for rapid skin clearance and comparatively long remissions.

References

Feb 1, 1978·The British Journal of Dermatology·P W Gould, L Wilson
Feb 1, 1978·The British Journal of Dermatology·W L MorisonT B Fitzpatrick
Jun 1, 1978·The British Journal of Dermatology·E ChristophersA Langner
Jul 1, 1976·Archives of Dermatology·K W WolffL Tannenbaum
Aug 1, 1976·Cancer·B A GilchrestT B Fitzpatrick
Jun 1, 1977·The Journal of Investigative Dermatology·J W MelskiH L Bleich
Apr 1, 1976·The Journal of Investigative Dermatology·E B Laurence, E Christophers
Dec 5, 1974·The New England Journal of Medicine·J A ParrishM A Pathak

❮ Previous
Next ❯

Citations

Jan 1, 1980·Archives of Dermatological Research·M LandthalerO Braun-Falco
May 4, 1979·Archives of Dermatological Research·G Heidbreder, E Christophers
Jan 1, 1981·Pharmacology & Therapeutics·K Wolff, H Hönigsmann
Jan 1, 1987·Pharmacology & Therapeutics·M T McEvoy, R S Stern
Feb 28, 2004·Journal of the American Academy of Dermatology·Mark LebwohlSteven R Feldman
Oct 1, 1979·The British Journal of Dermatology·H HönigsmannK Wolff
Mar 25, 2011·Journal of the American Academy of Dermatology·Whitney LapollaSteven R Feldman
Aug 1, 1980·Journal of the American Academy of Dermatology·R J Coskey
Aug 30, 2008·Clinics in Dermatology·Lars Alexander SchneiderKarin Scharffetter-Kochanek
Jan 1, 1982·Journal of the American Academy of Dermatology·W L MorisonT B Fitzpatrick
Nov 1, 1987·Journal of the American Academy of Dermatology·A K Gupta, T F Anderson
Nov 13, 2008·Photodermatology, Photoimmunology & Photomedicine·Donal O'KaneMotasim Badri
Sep 28, 2010·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Silja Domm, Ulrich Mrowietz
Feb 1, 1996·Journal of the American Academy of Dermatology·M A MenterM D Zanolli
Nov 1, 1981·Clinical and Experimental Dermatology·A P Warin
Jun 22, 2005·Journal of the American Academy of Dermatology·James Del Rosso, Sheila Fallon Friedlander
Sep 29, 2004·Dermatologic Clinics·David S Aaronson, Mark Lebwohl
Jan 1, 1994·The British Journal of Dermatology·E L Speight, P M Farr
Sep 1, 1980·International Journal of Dermatology·J A ParrishT B Fitzpatrick

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved